Article Cells, Cultured Cellular Senescence Culture Media, Conditioned Phenotype Proteomics aging atazanavir plus ritonavir cell aging cell culture cell cycle arrest conditioned medium controlled study data-independent acquisition disorders of mitochondrial functions doxorubicin gene expression human human cell lung fibroblast mass spectrometry messenger RNA phenotype polymerase chain reaction priority journal proteomics quantitative analysis quantitative proteomic analysis secretome senescence