In Vitro, In Vivo and In Silico Effectiveness of LASSBio-1386, an N-Acyl Hydrazone Derivative Phosphodiesterase-4 Inhibitor, Against Leishmania amazonensis

by Dahara Keyse Carvalho Silva, Dahara Keyse Carvalho Silva, Jessicada Silva Teixeira, Jessicada Silva Teixeira, Diogo Rodrigo Magalhães Moreira, Tiago Fernandes da Silva, Eliezer Jesus de Lacerda Barreiro, Humberto Fonseca de Freitas, Samuel Silva da Rocha Pita, André Lacerda Braga Teles, Elisalva Teixeira Guimarães, Elisalva Teixeira Guimarães, Milena Botelho Pereira Soares, Milena Botelho Pereira Soares
Published 2020-12-01

A Novel High-Content Screening-Based Method for Anti-Trypanosoma cruzi Drug Discovery Using Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes

by Diogo Crispim Nascimento Portella, Erik Aranha Rossi, Bruno Diaz Paredes, Tanira Matutino Bastos, Cássio Santana Meira, Carolina Vasques Kymie Nonaka, Daniela Nascimento Silva, Alex Improta-Caria, Diogo Rodrigo Magalhaes Moreira, Ana Cristina Lima Leite, Gevanio Bezerra de Oliveira Filho, José Maria Barbosa Filho, Ricardo Ribeiro dos Santos, Milena Botelho Pereira Soares, Bruno Solano de Freita Souza
Published 2021-01-01

Betulinic Acid Derivative BA5, Attenuates Inflammation and Fibrosis in Experimental Chronic Chagas Disease Cardiomyopathy by Inducing IL-10 and M2 Polarization

by Cássio Santana Meira, Emanuelle De Souza Santos, Renan Fernandes do Espírito Santo, Renan Fernandes do Espírito Santo, Juliana Fraga Vasconcelos, Juliana Fraga Vasconcelos, Iasmim Diniz Orge, Iasmim Diniz Orge, Carolina Kymie Vasques Nonaka, Carolina Kymie Vasques Nonaka, Breno Cardim Barreto, Breno Cardim Barreto, Alex Cleber Improta Caria, Daniela Nascimento Silva, Daniela Nascimento Silva, José Maria Barbosa-Filho, Simone Garcia Macambira, Simone Garcia Macambira, Diogo Rodrigo Magalhães Moreira, Milena Botelho Pereira Soares
Published 2019-06-01