Drug-tunable multidimensional synthetic gene control using inducible degron-tagged dCas9 effectors

by Dirk A. Kleinjan, Caroline Wardrope, Si Nga Sou, Susan J. Rosser
Published 2017-10-01

DNaseI hypersensitivity and ultraconservation reveal novel, interdependent long-range enhancers at the complex Pax6 cis-regulatory region.

by David J McBride, Adam Buckle, Veronica van Heyningen, Dirk A Kleinjan
Published 2011-01-01

The developmental regulator Pax6 is essential for maintenance of islet cell function in the adult mouse pancreas.

by Alan W Hart, Sebastien Mella, Jacek Mendrychowski, Veronica van Heyningen, Dirk A Kleinjan
Published 2013-01-01

Identification of genomic regions regulating Pax6 expression in embryonic forebrain using YAC reporter transgenic mouse lines.

by Da Mi, Yu-Ting Huang, Dirk A Kleinjan, John O Mason, David J Price
Published 2013-01-01

Functional assessment of disease-associated regulatory variants in vivo using a versatile dual colour transgenesis strategy in zebrafish.

by Shipra Bhatia, Christopher T Gordon, Robert G Foster, Lucie Melin, Véronique Abadie, Geneviève Baujat, Marie-Paule Vazquez, Jeanne Amiel, Stanislas Lyonnet, Veronica van Heyningen, Dirk A Kleinjan
Published 2015-06-01

Sequencing of Pax6 loci from the elephant shark reveals a family of Pax6 genes in vertebrate genomes, forged by ancient duplications and divergences.

by Vydianathan Ravi, Shipra Bhatia, Philippe Gautier, Felix Loosli, Boon-Hui Tay, Alice Tay, Emma Murdoch, Pedro Coutinho, Veronica van Heyningen, Sydney Brenner, Byrappa Venkatesh, Dirk A Kleinjan
Published 2013-01-01

Subfunctionalization of duplicated zebrafish pax6 genes by cis-regulatory divergence.

by Dirk A Kleinjan, Ruth M Bancewicz, Philippe Gautier, Ralf Dahm, Helia B Schonthaler, Giuseppe Damante, Anne Seawright, Ann M Hever, Patricia L Yeyati, Veronica van Heyningen, Pedro Coutinho
Published 2008-02-01