Exploration of Piperidinols as Potential Antitubercular Agents

by Areej Abuhammad, Elizabeth Fullam, Sanjib Bhakta, Angela J. Russell, Garrett M. Morris, Paul W. Finn, Edith Sim
Published 2014-10-01

Identification of NAD(P)H quinone oxidoreductase activity in azoreductases from P. aeruginosa: azoreductases and NAD(P)H quinone oxidoreductases belong to the same FMN-dependent su...

by Ali Ryan, Elise Kaplan, Jean-Christophe Nebel, Elena Polycarpou, Vincenzo Crescente, Edward Lowe, Gail M Preston, Edith Sim
Published 2014-01-01

From arylamine N-acetyltransferase to folate-dependent acetyl CoA hydrolase: impact of folic acid on the activity of (HUMAN)NAT1 and its homologue (MOUSE)NAT2.

by Nicola Laurieri, Julien Dairou, James E Egleton, Lesley A Stanley, Angela J Russell, Jean-Marie Dupret, Edith Sim, Fernando Rodrigues-Lima
Published 2014-01-01

A novel color change mechanism for breast cancer biomarker detection: naphthoquinones as specific ligands of human arylamine N-acetyltransferase 1.

by Nicola Laurieri, James E Egleton, Amy Varney, Cyrille C Thinnes, Camilo E Quevedo, Peter T Seden, Sam Thompson, Fernando Rodrigues-Lima, Julien Dairou, Jean-Marie Dupret, Angela J Russell, Edith Sim
Published 2013-01-01

Piperidinols that show anti-tubercular activity as inhibitors of arylamine N-acetyltransferase: an essential enzyme for mycobacterial survival inside macrophages.

by Areej Abuhammad, Elizabeth Fullam, Edward D Lowe, David Staunton, Akane Kawamura, Isaac M Westwood, Sanjib Bhakta, Alun Christopher Garner, David L Wilson, Peter T Seden, Stephen G Davies, Angela J Russell, Elspeth F Garman, Edith Sim
Published 2012-01-01

Pathogenic mycobacteria achieve cellular persistence by inhibiting the Niemann-Pick Type C disease cellular pathway [version 2; referees: 2 approved, 2 approved with reservations]

by Paul Fineran, Emyr Lloyd-Evans, Nathan A. Lack, Nick Platt, Lianne C. Davis, Anthony J. Morgan, Doris Höglinger, Raju Venkata V. Tatituri, Simon Clark, Ian M. Williams, Patricia Tynan, Nada Al Eisa, Evgeniya Nazarova, Ann Williams, Antony Galione, Daniel S. Ory, Gurdyal S. Besra, David G. Russell, Michael B. Brenner, Edith Sim, Frances M. Platt
Published 2017-06-01

Pathogenic mycobacteria achieve cellular persistence by inhibiting the Niemann-Pick Type C disease cellular pathway [version 1; referees: 2 approved, 1 approved with reservations]

by Paul Fineran, Emyr Lloyd-Evans, Nathan A. Lack, Nick Platt, Lianne C. Davis, Anthony J. Morgan, Doris Höglinger, Raju Venkata V. Tatituri, Simon Clark, Ian M. Williams, Patricia Tynan, Nada Al Eisa, Evgeniya Nazarova, Ann Williams, Antony Galione, Daniel S. Ory, Gurdyal S. Besra, David G. Russell, Michael B. Brenner, Edith Sim, Frances M. Platt
Published 2016-11-01