Ceramide and Ischemia/Reperfusion Injury

by Xingxuan He, Edward H. Schuchman
Published 2018-01-01

Recombinant human acid sphingomyelinase as an adjuvant to sorafenib treatment of experimental liver cancer.

by Radoslav Savić, Xingxuan He, Isabel Fiel, Edward H Schuchman
Published 2013-01-01

New paradigms for the treatment of lysosomal storage diseases: targeting the endocannabinoid system as a therapeutic strategy

by Edward H. Schuchman, Maria D. Ledesma, Calogera M. Simonaro
Published 2021-03-01

Acid Ceramidase Protects Against Hepatic Ischemia/Reperfusion Injury by Modulating Sphingolipid Metabolism and Reducing Inflammation and Oxidative Stress

by Yuan Jiang, Yuan Jiang, Xingxuan He, Calogera M. Simonaro, Bin Yi, Edward H. Schuchman
Published 2021-05-01

A lipid analogue that inhibits sphingomyelin hydrolysis and synthesis, increases ceramide, and leads to cell death

by Peter I. Darroch, Arie Dagan, Tami Granot, Xingxuan He, Shimon Gatt, Edward H. Schuchman
Published 2005-11-01

Inhibition of fatty acid amide hydrolase prevents pathology in neurovisceral acid sphingomyelinase deficiency by rescuing defective endocannabinoid signaling

by Adrián Bartoll, Ana Toledano‐Zaragoza, Josefina Casas, Manuel Guzmán, Edward H Schuchman, María Dolores Ledesma
Published 2020-11-01

Anti-TNF-alpha therapy enhances the effects of enzyme replacement therapy in rats with mucopolysaccharidosis type VI.

by Efrat Eliyahu, Theodore Wolfson, Yi Ge, Karl J Jepsen, Edward H Schuchman, Calogera M Simonaro
Published 2011-01-01

Dose responsive effects of subcutaneous pentosan polysulfate injection in mucopolysaccharidosis type VI rats and comparison to oral treatment.

by Michael Frohbergh, Yi Ge, Fanli Meng, Nesrin Karabul, Alexander Solyom, Alon Lai, James Iatridis, Edward H Schuchman, Calogera M Simonaro
Published 2014-01-01

Apolipoprotein D-mediated preservation of lysosomal function promotes cell survival and delays motor impairment in Niemann-Pick type A disease

by Raquel Pascua-Maestro, Miriam Corraliza-Gomez, Cristian Fadrique-Rojo, Maria D. Ledesma, Edward H. Schuchman, Diego Sanchez, Maria D. Ganfornina
Published 2020-10-01

Pharmacological reversion of sphingomyelin‐induced dendritic spine anomalies in a Niemann Pick disease type A mouse model

by Ana I Arroyo, Paola G Camoletto, Laura Morando, Marco Sassoe‐Pognetto, Maurizio Giustetto, Paul P Van Veldhoven, Edward H Schuchman, Maria D Ledesma
Published 2014-03-01

Ceramides are necessary and sufficient for diet-induced impairment of thermogenic adipocytes

by Bhagirath Chaurasia, Li Ying, Chad Lamar Talbot, John Alan Maschek, James Cox, Edward H. Schuchman, Yoshio Hirabayashi, William L. Holland, Scott A. Summers
Published 2021-03-01

Pentosan polysulfate: a novel therapy for the mucopolysaccharidoses.

by Edward H Schuchman, Yi Ge, Alon Lai, Yury Borisov, Meghan Faillace, Efrat Eliyahu, Xingxuan He, James Iatridis, Helen Vlassara, Gary Striker, Calogera M Simonaro
Published 2013-01-01

Signalling Effects Induced by Acid Ceramidase in Human Epithelial Or Leukemic Cell Lines

by Käthe Baduva, Lara Büchter, Katja Kreyenkamp, Linnea Westphal, Barbara Wilker, Marcus Kohnen, Edward H. Schuchman, Michael J. Edwards, Katrin Anne Becker, Erich Gulbins, Alexander Carpinteiro
Published 2019-04-01

Pentosan Polysulfate: Oral Versus Subcutaneous Injection in Mucopolysaccharidosis Type I Dogs.

by Calogera M Simonaro, Shunji Tomatsu, Tracy Sikora, Francyne Kubaski, Michael Frohbergh, Johana M Guevara, Raymond Y Wang, Moin Vera, Jennifer L Kang, Lachlan J Smith, Edward H Schuchman, Mark E Haskins
Published 2016-01-01

Acid ceramidase maintains the chondrogenic phenotype of expanded primary chondrocytes and improves the chondrogenic differentiation of bone marrow-derived mesenchymal stem cells.

by Calogera M Simonaro, Sylvain Sachot, Yi Ge, Xingxuan He, Victor A Deangelis, Efrat Eliyahu, Daniel J Leong, Hui B Sun, Jeffrey B Mason, Mark E Haskins, Dean W Richardson, Edward H Schuchman
Published 2013-01-01

Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer’s Disease

by Ju Youn Lee, Seung Hoon Han, Min Hee Park, Bosung Baek, Im-Sook Song, Min-Koo Choi, Yoh Takuwa, Hoon Ryu, Seung Hyun Kim, Xingxuan He, Edward H. Schuchman, Jae-Sung Bae, Hee Kyung Jin
Published 2018-04-01

Multi-omic profiles of hepatic metabolism in TPN-fed preterm pigs administered new generation lipid emulsions

by Gregory Guthrie, Madhulika Kulkarni, Hester Vlaardingerbroek, Barbara Stoll, Kenneth Ng, Camilia Martin, John Belmont, Darryl Hadsell, William Heird, Christopher B. Newgard, Oluyinka Olutoye, Johannes van Goudoever, Charlotte Lauridsen, Xingxuan He, Edward H. Schuchman, Douglas Burrin
Published 2016-09-01

N-AS-triggered SPMs are direct regulators of microglia in a model of Alzheimer’s disease

by Ju Youn Lee, Seung Hoon Han, Min Hee Park, Im-Sook Song, Min-Koo Choi, Eunsoo Yu, Cheol-Min Park, Hee-Jin Kim, Seung Hyun Kim, Edward H. Schuchman, Hee Kyung Jin, Jae-sung Bae
Published 2020-05-01

Quantitative Systems Pharmacology Modeling of Acid Sphingomyelinase Deficiency and the Enzyme Replacement Therapy Olipudase Alfa Is an Innovative Tool for Linking Pathophysiology a...

by Chanchala D. Kaddi, Bradley Niesner, Rena Baek, Paul Jasper, John Pappas, John Tolsma, Jing Li, Zachary van Rijn, Mengdi Tao, Catherine Ortemann‐Renon, Rachael Easton, Sharon Tan, Ana Cristina Puga, Edward H. Schuchman, Jeffrey S. Barrett, Karim Azer
Published 2018-07-01