5-Azacytidine Potentiates Anti-tumor Immunity in a Model of Pancreatic Ductal Adenocarcinoma

by Nancy D. Ebelt, Edith Zuniga, Benjamin L. Johnson, Don J. Diamond, Edwin R. Manuel
Published 2020-03-01

<i>Salmonella</i>-Based Therapy Targeting Indoleamine 2,3-Dioxygenase Restructures the Immune Contexture to Improve Checkpoint Blockade Efficacy

by Nancy D. Ebelt, Edith Zuniga, Monica Marzagalli, Vic Zamloot, Bruce R. Blazar, Ravi Salgia, Edwin R. Manuel
Published 2020-12-01

Collagenase-Expressing <i>Salmonella</i> Targets Major Collagens in Pancreatic Cancer Leading to Reductions in Immunosuppressive Subsets and Tumor Growth

by Nancy D. Ebelt, Vic Zamloot, Edith Zuniga, Kevin B. Passi, Lukas J. Sobocinski, Cari A. Young, Bruce R. Blazar, Edwin R. Manuel
Published 2021-07-01

Desmoplasia and oncogene driven acinar-to-ductal metaplasia are concurrent events during acinar cell-derived pancreatic cancer initiation in young adult mice.

by Benjamin L Johnson, Marcela d'Alincourt Salazar, Sarah Mackenzie-Dyck, Massimo D'Apuzzo, Hung Ping Shih, Edwin R Manuel, Don J Diamond
Published 2019-01-01

Metronomic Doses of Temozolomide Enhance the Efficacy of Carbon Nanotube CpG Immunotherapy in an Invasive Glioma Model.

by Mao Ouyang, Ethan E White, Hui Ren, Qin Guo, Ian Zhang, Hang Gao, Song Yanyan, Xuebo Chen, Yiming Weng, Anna Da Fonseca, Sunny Shah, Edwin R Manuel, Leying Zhang, Steven L Vonderfecht, Darya Alizadeh, Jacob M Berlin, Behnam Badie
Published 2016-01-01

Phenotypic Switching of Naïve T Cells to Immune-Suppressive Treg-Like Cells by Mutant KRAS

by Arjun Kalvala, Pierre Wallet, Lu Yang, Chongkai Wang, Haiqing Li, Arin Nam, Anusha Nathan, Isa Mambetsariev, Valeriy Poroyko, Hanlin Gao, Peiguo Chu, Martin Sattler, Andrea Bild, Edwin R. Manuel, Peter P. Lee, Mohit Kumar Jolly, Prakash Kulkarni, Ravi Salgia
Published 2019-10-01

Development of a multi-antigenic SARS-CoV-2 vaccine candidate using a synthetic poxvirus platform

by Flavia Chiuppesi, Marcela d’Alincourt Salazar, Heidi Contreras, Vu H. Nguyen, Joy Martinez, Yoonsuh Park, Jenny Nguyen, Mindy Kha, Angelina Iniguez, Qiao Zhou, Teodora Kaltcheva, Roman Levytskyy, Nancy D. Ebelt, Tae Hyuk Kang, Xiwei Wu, Thomas F. Rogers, Edwin R. Manuel, Yuriy Shostak, Don J. Diamond, Felix Wussow
Published 2020-11-01