Estudo dos fatores envolvidos na formação de corpúsculos lipídicos, induzido por uma fosfolipase A2, isolada do veneno de serpente: síntese e metabolismo de lipídeos.

by Elbio Leiguez Junior
Published 2015

A Metalloproteinase Induces an Inflammatory Response in Preadipocytes with the Activation of COX Signalling Pathways and Participation of Endogenous Phospholipases A₂

by Priscila Motta Janovits, Elbio Leiguez, Viviane Portas, Catarina Teixeira
Published 2021-06-01

Inflammation Induced by Platelet-Activating Viperid Snake Venoms: Perspectives on Thromboinflammation

by Catarina Teixeira, Catarina Teixeira, Cristina Maria Fernandes, Cristina Maria Fernandes, Elbio Leiguez, Elbio Leiguez, Ana Marisa Chudzinski-Tavassi, Ana Marisa Chudzinski-Tavassi
Published 2019-09-01

A Representative GIIA Phospholipase A₂ Activates Preadipocytes to Produce Inflammatory Mediators Implicated in Obesity Development

by Elbio Leiguez, Priscila Motta, Rodrigo Maia Marques, Bruno Lomonte, Suely Vilela Sampaio, Catarina Teixeira
Published 2020-11-01

A Lipidomic Perspective of the Action of Group IIA Secreted Phospholipase A₂ on Human Monocytes: Lipid Droplet Biogenesis and Activation of Cytosolic Phospholipase A<sub...

by Juan P. Rodríguez, Elbio Leiguez, Carlos Guijas, Bruno Lomonte, José M. Gutiérrez, Catarina Teixeira, María A. Balboa, Jesús Balsinde
Published 2020-06-01

A representative metalloprotease induces PGE2 synthesis in fibroblast-like synoviocytes via the NF-κB/COX-2 pathway with amplification by IL-1β and the EP4 receptor

by Mariana N. Viana, Elbio Leiguez, José M. Gutiérrez, Alexandra Rucavado, Regina P. Markus, Marina Marçola, Catarina Teixeira, Cristina M. Fernandes
Published 2020-02-01

A Lys49 Phospholipase A2, Isolated from Bothrops asper Snake Venom, Induces Lipid Droplet Formation in Macrophages Which Depends on Distinct Signaling Pathways and the C-Terminal...

by Karina Cristina Giannotti, Elbio Leiguez, Vanessa Moreira, Neide Galvão Nascimento, Bruno Lomonte, José Maria Gutiérrez, Robson Lopes de Melo, Catarina Teixeira
Published 2013-01-01

A Snake Venom-Secreted Phospholipase A2 Induces Foam Cell Formation Depending on the Activation of Factors Involved in Lipid Homeostasis

by Elbio Leiguez, Karina Cristina Giannotti, Mariana do Nascimento Viana, Márcio Hideki Matsubara, Cristina Maria Fernandes, José Maria Gutiérrez, Bruno Lomonte, Catarina Teixeira
Published 2018-01-01

Critical role of TLR2 and MyD88 for functional response of macrophages to a group IIA-secreted phospholipase A2 from snake venom.

by Elbio Leiguez, Karina Cristina Giannotti, Vanessa Moreira, Márcio Hideki Matsubara, José María Gutiérrez, Bruno Lomonte, Juan Pablo Rodríguez, Jesús Balsinde, Catarina Teixeira
Published 2014-01-01

Crotalus durissus ruruima Snake Venom and a Phospholipase A2 Isolated from This Venom Elicit Macrophages to Form Lipid Droplets and Synthesize Inflammatory Lipid Mediators

by Ana Eduarda Zulim de Carvalho, Karina Giannotti, Elbio Leiguez Junior, Márcio Matsubara, Maria Cristina Dos Santos, Consuelo Latorre Fortes-Dias, Catarina Teixeira
Published 2019-01-01

A snake venom group IIA PLA2 with immunomodulatory activity induces formation of lipid droplets containing 15-d-PGJ2 in macrophages

by Karina Cristina Giannotti, Elbio Leiguez, Ana Eduarda Zulim de Carvalho, Neide Galvão Nascimento, Márcio Hideki Matsubara, Consuelo Latorre Fortes-Dias, Vanessa Moreira, Catarina Teixeira
Published 2017-06-01

A Secreted Phospholipase A₂ Induces Formation of Smooth Muscle Foam Cells Which Transdifferentiate to Macrophage-Like State

by Karina Cristina Giannotti, Sönke Weinert, Mariana Nascimento Viana, Elbio Leiguez, Thaís L. S. Araujo, Francisco R. M. Laurindo, Bruno Lomonte, Rüdiger Braun-Dullaeus, Catarina Teixeira
Published 2019-09-01