BH3-mimetics- and cisplatin-induced cell death proceeds through different pathways depending on the availability of death-related cellular components.

by Vicente Andreu-Fernández, Ainhoa Genovés, Angel Messeguer, Mar Orzáez, Mónica Sancho, Enrique Pérez-Payá
Published 2013-01-01

Altered mitochondria morphology and cell metabolism in Apaf1-deficient cells.

by Mónica Sancho, Anna Gortat, Andrés E Herrera, Vicente Andreu-Fernández, Elisabetta Ferraro, Francesco Cecconi, Mar Orzáez, Enrique Pérez-Payá
Published 2014-01-01

L-Aminoacid Oxidase from Bothrops leucurus Venom Induces Nephrotoxicity via Apoptosis and Necrosis.

by Isabel C O Morais, Gustavo J S Pereira, Gustavo J S Pereira, M Orzáez, Roberta J B Jorge, Claudia Bincoletto, Marcos H Toyama, Helena S A Monteiro, Soraya S Smaili, Enrique Pérez-Payá, Alice M C Martins
Published 2015-01-01

Apaf-1 inhibitors protect from unwanted cell death in in vivo models of kidney ischemia and chemotherapy induced ototoxicity.

by Mar Orzáez, Mónica Sancho, Sandra Marchán, Laura Mondragón, Rebeca Montava, Juan García Valero, Olatz Landeta, Gorka Basañez, Rodrigo J Carbajo, Antonio Pineda-Lucena, Jordi Bujons, Alejandra Moure, Angel Messeguer, Carmen Lagunas, Carmen Herrero, Enrique Pérez-Payá
Published 2014-01-01

A nanoconjugate Apaf-1 inhibitor protects mesothelial cells from cytokine-induced injury.

by Beatriz Santamaría, Alberto Benito-Martin, Alvaro Conrado Ucero, Luiz Stark Aroeira, Ana Reyero, María Jesús Vicent, Mar Orzáez, Angel Celdrán, Jaime Esteban, Rafael Selgas, Marta Ruíz-Ortega, Marta Ruíz-Ortega, Manuel López Cabrera, Jesús Egido, Enrique Pérez-Payá, Alberto Ortiz
Published 2009-08-01