X-ray crystal structure of the ancestral 3-ketosteroid receptor-progesterone-mifepristone complex shows mifepristone bound at the coactivator binding interface.

by Jennifer K Colucci, Eric A Ortlund
Published 2013-01-01

Crystal structure of the mineralocorticoid receptor DNA binding domain in complex with DNA.

by William H Hudson, Christine Youn, Eric A Ortlund
Published 2014-01-01

Mechanisms for the evolution of a derived function in the ancestral glucocorticoid receptor.

by Sean Michael Carroll, Eric A Ortlund, Joseph W Thornton
Published 2011-06-01

Ligand-Induced Allosteric Effects Governing SR Signaling

by C. Denise Okafor, Jennifer K. Colucci, Eric A. Ortlund
Published 2019-04-01

Vestigialization of an allosteric switch: genetic and structural mechanisms for the evolution of constitutive activity in a steroid hormone receptor.

by Jamie T Bridgham, June Keay, Eric A Ortlund, Joseph W Thornton
Published 2014-01-01

Evolution of minimal specificity and promiscuity in steroid hormone receptors.

by Geeta N Eick, Jennifer K Colucci, Michael J Harms, Eric A Ortlund, Joseph W Thornton
Published 2012-01-01

Identification of a lipid scrambling domain in ANO6/TMEM16F

by Kuai Yu, Jarred M Whitlock, Kyleen Lee, Eric A Ortlund, Yuan Yuan Cui, H Criss Hartzell
Published 2015-06-01

Enantiomer-specific activities of an LRH-1 and SF-1 dual agonist

by Suzanne G. Mays, Józef Stec, Xu Liu, Emma H. D’Agostino, Richard J. Whitby, Eric A. Ortlund
Published 2020-12-01

The Rho-GEF PIX-1 directs assembly or stability of lateral attachment structures between muscle cells

by Jasmine C. Moody, Hiroshi Qadota, April R. Reedy, C. Denise Okafor, Niveda Shanmugan, Yohei Matsunaga, Courtney J. Christian, Eric A. Ortlund, Guy M. Benian
Published 2020-10-01

Protein evolution by molecular tinkering: diversification of the nuclear receptor superfamily from a ligand-dependent ancestor.

by Jamie T Bridgham, Geeta N Eick, Claire Larroux, Kirti Deshpande, Michael J Harms, Marie E A Gauthier, Eric A Ortlund, Bernard M Degnan, Joseph W Thornton
Published 2010-10-01

Cryptic glucocorticoid receptor-binding sites pervade genomic NF-κB response elements

by William H. Hudson, Ian Mitchelle S. de Vera, Jerome C. Nwachukwu, Emily R. Weikum, Austin G. Herbst, Qin Yang, David L. Bain, Kendall W. Nettles, Douglas J. Kojetin, Eric A. Ortlund
Published 2018-04-01

Thioesterase superfamily member 1 undergoes stimulus-coupled conformational reorganization to regulate metabolism in mice

by Yue Li, Norihiro Imai, Hayley T. Nicholls, Blaine R. Roberts, Samaksh Goyal, Tibor I. Krisko, Lay-Hong Ang, Matthew C. Tillman, Anne M. Roberts, Mahnoor Baqai, Eric A. Ortlund, David E. Cohen, Susan J. Hagen
Published 2021-06-01

Proline-Rich Acidic Protein 1 (PRAP1) Protects the Gastrointestinal Epithelium From Irradiation-Induced ApoptosisSummary

by Alexandra A. Wolfarth, Xu Liu, Trevor M. Darby, Darra J. Boyer, Jocelyn B. Spizman, Joshua A. Owens, Bindu Chandrasekharan, Crystal R. Naudin, Krisztina Z. Hanley, Brian S. Robinson, Eric A. Ortlund, Rheinallt M. Jones, Andrew S. Neish
Published 2020-01-01

The Effect of Anticoagulants, Temperature, and Time on the Human Plasma Metabolome and Lipidome from Healthy Donors as Determined by Liquid Chromatography-Mass Spectrometry

by Manoj Khadka, Andrei Todor, Kristal M. Maner-Smith, Jennifer K. Colucci, ViLinh Tran, David A. Gaul, Evan J. Anderson, Muktha S. Natrajan, Nadine Rouphael, Mark J. Mulligan, Circe E. McDonald, Mehul Suthar, Shuzhao Li, Eric A. Ortlund
Published 2019-05-01

High-resolution plasma metabolomics analysis to detect Mycobacterium tuberculosis-associated metabolites that distinguish active pulmonary tuberculosis in humans.

by Jeffrey M Collins, Douglas I Walker, Dean P Jones, Nestani Tukvadze, Ken H Liu, ViLinh T Tran, Karan Uppal, Jennifer K Frediani, Kirk A Easley, Neeta Shenvi, Manoj Khadka, Eric A Ortlund, Russell R Kempker, Henry M Blumberg, Thomas R Ziegler
Published 2018-01-01

Alterations in the Human Plasma Lipidome in Response to Tularemia Vaccination

by Kristal M. Maner-Smith, Johannes B. Goll, Manoj Khadka, Travis L. Jensen, Jennifer K. Colucci, Casey E. Gelber, Carolyn J. Albert, Steven E. Bosinger, Jacob D. Franke, Muktha Natrajan, Nadine Rouphael, Robert A. Johnson, Patrick Sanz, Evan J. Anderson, Daniel F. Hoft, Mark J. Mulligan, David A. Ford, Eric A. Ortlund
Published 2020-07-01