Erkki Ruoslahti
Erkki Ruoslahti (born 16 February 1940 in Imatra, Finland) is a cancer researcher and distinguished professor at Sanford Burnham Prebys Medical Discovery Institute. He moved from Finland to the United States in 1976.Ruoslahti made seminal contributions to biology of extracellular matrix and its receptors. He was one of the discoverers of fibronectin, an adhesion molecule and component of extracellular matrices, and he subsequently identified and cloned a number of other extracellular matrix components and adhesion molecules. In 1984, he identified the sequence within fibronectin that mediates cell attachment, called RGD for the amino acids of which it’s composed, and isolated the cellular receptors that bind that sequence, now known as integrins. The RGD discovery has led to the development of drugs for vascular thrombosis and cancer, among other diseases.
Ruoslahti currently studies specific marker molecules in blood vessels. He introduced the concept of vascular "zip codes," the idea that each tissue bears molecular signatures that can be targeted by affinity ligands, and used in vivo peptide phage display to prove the concept and develop numerous tumor-homing peptides. Provided by Wikipedia
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1by Xiangyou Liu, Gary B. Braun, Mingde Qin, Erkki Ruoslahti, Kazuki N. SugaharaGet full text
Published 2017-08-01
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4by Priya Prakash Karmali, Chris Brunquell, Hau Tram, Shubha Kale Ireland, Erkki Ruoslahti, Hector BiliranGet full text
Published 2011-01-01
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7by Aman P. Mann, Pablo Scodeller, Sazid Hussain, Gary B. Braun, Tarmo Mölder, Kadri Toome, Rajesh Ambasudhan, Tambet Teesalu, Stuart A. Lipton, Erkki RuoslahtiGet full text
Published 2017-11-01
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8by Aman P. Mann, Pablo Scodeller, Sazid Hussain, Gary B. Braun, Tarmo Mölder, Kadri Toome, Rajesh Ambasudhan, Tambet Teesalu, Stuart A. Lipton, Erkki RuoslahtiGet full text
Published 2018-03-01
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9by Tatiana Hurtado de Mendoza, Evangeline S. Mose, Gregory P. Botta, Gary B. Braun, Venkata R. Kotamraju, Randall P. French, Kodai Suzuki, Norio Miyamura, Tambet Teesalu, Erkki Ruoslahti, Andrew M. Lowy, Kazuki N. SugaharaGet full text
Published 2021-03-01
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10by Aman P. Mann, Pablo Scodeller, Sazid Hussain, Jinmyoung Joo, Ester Kwon, Gary B. Braun, Tarmo Mölder, Zhi-Gang She, Venkata Ramana Kotamraju, Barbara Ranscht, Stan Krajewski, Tambet Teesalu, Sangeeta Bhatia, Michael J. Sailor, Erkki RuoslahtiGet full text
Published 2016-06-01
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11by Yen Ling Yeow, Venkata Ramana Kotamraju, Xiao Wang, Meenu Chopra, Nasibah Azme, Jiansha Wu, Tobias D Schoep, Derek S Delaney, Kirk Feindel, Ji Li, Kelsey M Kennedy, Wes M Allen, Brendan F Kennedy, Irma Larma, David D Sampson, Lisa M Mahakian, Brett Z Fite, Hua Zhang, Tomas Friman, Aman P Mann, Farah A Aziz, M Priyanthi Kumarasinghe, Mikael Johansson, Hooi C Ee, George Yeoh, Lingjun Mou, Katherine W Ferrara, Hector Billiran, Ruth Ganss, Erkki Ruoslahti, Juliana HamzahGet full text
Published 2019-12-01
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