Targeting α-synuclein for PD Therapeutics: A Pursuit on All Fronts

by Margaux Teil, Marie-Laure Arotcarena, Emilie Faggiani, Florent Laferriere, Erwan Bezard, Benjamin Dehay
Published 2020-03-01

Overexpression of α-Synuclein by Oligodendrocytes in Transgenic Mice Does Not Recapitulate the Fibrillar Aggregation Seen in Multiple System Atrophy

by Florent Laferrière, Xin He, Federica Zinghirino, Evelyne Doudnikoff, Emilie Faggiani, Wassilios G. Meissner, Erwan Bezard, Francesca De Giorgi, François Ichas
Published 2020-10-01

Quaternary structure of pathological prion protein as a determining factor of strain-specific prion replication dynamics.

by Florent Laferrière, Philippe Tixador, Mohammed Moudjou, Jérôme Chapuis, Pierre Sibille, Laetitia Herzog, Fabienne Reine, Emilie Jaumain, Hubert Laude, Human Rezaei, Vincent Béringue
Published 2013-01-01

Functional and dynamic polymerization of the ALS-linked protein TDP-43 antagonizes its pathologic aggregation

by Tariq Afroz, Eva-Maria Hock, Patrick Ernst, Chiara Foglieni, Melanie Jambeau, Larissa A. B. Gilhespy, Florent Laferriere, Zuzanna Maniecka, Andreas Plückthun, Peer Mittl, Paolo Paganetti, Frédéric H. T. Allain, Magdalini Polymenidou
Published 2017-06-01

Protease resistance of infectious prions is suppressed by removal of a single atom in the cellular prion protein.

by Henning Leske, Simone Hornemann, Uli Simon Herrmann, Caihong Zhu, Paolo Dametto, Bei Li, Florent Laferriere, Magdalini Polymenidou, Pawel Pelczar, Regina Rose Reimann, Petra Schwarz, Elisabeth Jane Rushing, Kurt Wüthrich, Adriano Aguzzi
Published 2017-01-01