Oncostatin M mediates STAT3-dependent intestinal epithelial restitution via increased cell proliferation, decreased apoptosis and upregulation of SERPIN family members.

by Florian Beigel, Matthias Friedrich, Corina Probst, Karl Sotlar, Burkhard Göke, Julia Diegelmann, Stephan Brand
Published 2014-01-01

Design and validation of a disease network of inflammatory processes in the NSG-UC mouse model

by Henrika Jodeleit, Pia Palamides, Florian Beigel, Thomas Mueller, Eckhard Wolf, Matthias Siebeck, Roswitha Gropp
Published 2017-12-01

Rate and predictors of mucosal healing in patients with inflammatory bowel disease treated with anti-TNF-alpha antibodies.

by Florian Beigel, Matthias Deml, Fabian Schnitzler, Simone Breiteneicher, Burkhard Göke, Thomas Ochsenkühn, Stephan Brand
Published 2014-01-01

The PI3K pathway as a therapeutic intervention point in inflammatory bowel disease

by Paula Winkelmann, Anna‐Lena Unterweger, Diya Khullar, Florian Beigel, Leandra Koletzko, Matthias Siebeck, Roswitha Gropp
Published 2021-09-01

Targeting ulcerative colitis by suppressing glucose uptake with ritonavir

by Henrika Jodeleit, Omar Al-Amodi, Janina Caesar, Christina Villarroel Aguilera, Lesca Holdt, Roswitha Gropp, Florian Beigel, Matthias Siebeck
Published 2018-11-01

A mouse model for ulcerative colitis based on NOD-scid IL2R γnull mice reconstituted with peripheral blood mononuclear cells from affected individuals

by Pia Palamides, Henrika Jodeleit, Michael Föhlinger, Florian Beigel, Nadja Herbach, Thomas Mueller, Eckhard Wolf, Matthias Siebeck, Roswitha Gropp
Published 2016-09-01

Comparative analysis of the lambda-interferons IL-28A and IL-29 regarding their transcriptome and their antiviral properties against hepatitis C virus.

by Julia Diegelmann, Florian Beigel, Kathrin Zitzmann, Artur Kaul, Burkhard Göke, Christoph J Auernhammer, Ralf Bartenschlager, Helmut M Diepolder, Stephan Brand
Published 2010-12-01

Autoantibodies as diagnostic markers and potential drivers of inflammation in ulcerative colitis.

by Henrika Jodeleit, Lisa Milchram, Regina Soldo, Gabriel Beikircher, Silvia Schönthaler, Omar Al-Amodi, Eckhard Wolf, Florian Beigel, Andreas Weinhäusel, Matthias Siebeck, Roswitha Gropp
Published 2020-01-01

Head-to-head study of oxelumab and adalimumab in a mouse model of ulcerative colitis based on NOD/Scid IL2Rγnull mice reconstituted with human peripheral blood mononuclear cells

by Henrika Jodeleit, Paula Winkelmann, Janina Caesar, Sebastian Sterz, Lesca M. Holdt, Florian Beigel, Johannes Stallhofer, Simone Breiteneicher, Eckart Bartnik, Thomas Leeuw, Matthias Siebeck, Roswitha Gropp
Published 2021-01-01

The role of osteopontin (OPN/SPP1) haplotypes in the susceptibility to Crohn's disease.

by Jürgen Glas, Julia Seiderer, Corinna Bayrle, Martin Wetzke, Christoph Fries, Cornelia Tillack, Torsten Olszak, Florian Beigel, Christian Steib, Matthias Friedrich, Julia Diegelmann, Darina Czamara, Stephan Brand
Published 2011-01-01

Development of a uniform, very aggressive disease phenotype in all homozygous carriers of the NOD2 mutation p.Leu1007fsX1008 with Crohn's disease and active smoking status resultin...

by Fabian Schnitzler, Matthias Friedrich, Marianne Angelberger, Julia Diegelmann, Johannes Stallhofer, Christiane Wolf, Joel Dütschler, Samuel Truniger, Torsten Olszak, Florian Beigel, Cornelia Tillack, Peter Lohse, Stephan Brand
Published 2020-01-01

The NOD2 p.Leu1007fsX1008 mutation (rs2066847) is a stronger predictor of the clinical course of Crohn's disease than the FOXO3A intron variant rs12212067.

by Fabian Schnitzler, Matthias Friedrich, Christiane Wolf, Marianne Angelberger, Julia Diegelmann, Torsten Olszak, Florian Beigel, Cornelia Tillack, Johannes Stallhofer, Burkhard Göke, Jürgen Glas, Peter Lohse, Stephan Brand
Published 2014-01-01

The NOD2 Single Nucleotide Polymorphism rs72796353 (IVS4+10 A>C) Is a Predictor for Perianal Fistulas in Patients with Crohn's Disease in the Absence of Other NOD2 Mutations.

by Fabian Schnitzler, Matthias Friedrich, Christiane Wolf, Johannes Stallhofer, Marianne Angelberger, Julia Diegelmann, Torsten Olszak, Cornelia Tillack, Florian Beigel, Burkhard Göke, Jürgen Glas, Peter Lohse, Stephan Brand
Published 2015-01-01

IRGM variants and susceptibility to inflammatory bowel disease in the German population.

by Jürgen Glas, Julia Seiderer, Stephanie Bues, Johannes Stallhofer, Christoph Fries, Torsten Olszak, Eleni Tsekeri, Martin Wetzke, Florian Beigel, Christian Steib, Matthias Friedrich, Burkhard Göke, Julia Diegelmann, Darina Czamara, Stephan Brand
Published 2013-01-01

PTPN2 gene variants are associated with susceptibility to both Crohn's disease and ulcerative colitis supporting a common genetic disease background.

by Jürgen Glas, Johanna Wagner, Julia Seiderer, Torsten Olszak, Martin Wetzke, Florian Beigel, Cornelia Tillack, Johannes Stallhofer, Matthias Friedrich, Christian Steib, Burkhard Göke, Thomas Ochsenkühn, Nazanin Karbalai, Julia Diegelmann, Darina Czamara, Stephan Brand
Published 2012-01-01

Analysis of IL12B gene variants in inflammatory bowel disease.

by Jürgen Glas, Julia Seiderer, Johanna Wagner, Torsten Olszak, Christoph Fries, Cornelia Tillack, Matthias Friedrich, Florian Beigel, Johannes Stallhofer, Christian Steib, Martin Wetzke, Burkhard Göke, Thomas Ochsenkühn, Julia Diegelmann, Darina Czamara, Stephan Brand
Published 2012-01-01

The NOD2 single nucleotide polymorphisms rs2066843 and rs2076756 are novel and common Crohn's disease susceptibility gene variants.

by Jürgen Glas, Julia Seiderer, Cornelia Tillack, Simone Pfennig, Florian Beigel, Matthias Jürgens, Torsten Olszak, Rüdiger P Laubender, Maria Weidinger, Bertram Müller-Myhsok, Burkhard Göke, Thomas Ochsenkühn, Peter Lohse, Julia Diegelmann, Darina Czamara, Stephan Brand
Published 2010-01-01

Evidence for STAT4 as a common autoimmune gene: rs7574865 is associated with colonic Crohn's disease and early disease onset.

by Jürgen Glas, Julia Seiderer, Melinda Nagy, Christoph Fries, Florian Beigel, Maria Weidinger, Simone Pfennig, Wolfram Klein, Jörg T Epplen, Peter Lohse, Matthias Folwaczny, Burkhard Göke, Thomas Ochsenkühn, Julia Diegelmann, Bertram Müller-Myhsok, Darina Roeske, Stephan Brand
Published 2010-01-01

CEACAM6 gene variants in inflammatory bowel disease.

by Jürgen Glas, Julia Seiderer, Christoph Fries, Cornelia Tillack, Simone Pfennig, Maria Weidinger, Florian Beigel, Torsten Olszak, Ulrich Lass, Burkhard Göke, Thomas Ochsenkühn, Christiane Wolf, Peter Lohse, Bertram Müller-Myhsok, Julia Diegelmann, Darina Czamara, Stephan Brand
Published 2011-01-01

Solid Organ Transplantation in Patients with Inflammatory Bowel Diseases (IBD): Analysis of Transplantation Outcome and IBD Activity in a Large Single Center Cohort.

by Fabian Schnitzler, Matthias Friedrich, Johannes Stallhofer, Ulf Schönermarck, Michael Fischereder, Antje Habicht, Nazanin Karbalai, Christiane Wolf, Marianne Angelberger, Torsten Olszak, Florian Beigel, Cornelia Tillack, Burkhard Göke, Reinhart Zachoval, Gerald Denk, Markus Guba, Christian Rust, Norbert Grüner, Stephan Brand
Published 2015-01-01