Antisense Oligonucleotides Used to Target the DUX4 mRNA as Therapeutic Approaches in FaciosScapuloHumeral Muscular Dystrophy (FSHD)

by Eugénie Ansseau, Céline Vanderplanck, Armelle Wauters, Scott Q. Harper, Frédérique Coppée, Alexandra Belayew
Published 2017-03-01

The FSHD atrophic myotube phenotype is caused by DUX4 expression.

by Céline Vanderplanck, Eugénie Ansseau, Sébastien Charron, Nadia Stricwant, Alexandra Tassin, Dalila Laoudj-Chenivesse, Steve D Wilton, Frédérique Coppée, Alexandra Belayew
Published 2011-01-01

Overexpression of the double homeodomain protein DUX4c interferes with myofibrillogenesis and induces clustering of myonuclei

by Céline Vanderplanck, Alexandra Tassin, Eugénie Ansseau, Sébastien Charron, Armelle Wauters, Céline Lancelot, Kelly Vancutsem, Dalila Laoudj-Chenivesse, Alexandra Belayew, Frédérique Coppée
Published 2018-01-01

FSHD myotubes with different phenotypes exhibit distinct proteomes.

by Alexandra Tassin, Baptiste Leroy, Dalila Laoudj-Chenivesse, Armelle Wauters, Céline Vanderplanck, Marie-Catherine Le Bihan, Frédérique Coppée, Ruddy Wattiez, Alexandra Belayew
Published 2012-01-01

Induction of a local muscular dystrophy using electroporation in vivo: an easy tool for screening therapeutics

by Aline Derenne, Alexandra Tassin, Thuy Hang Nguyen, Estelle De Roeck, Vincianne Jenart, Eugénie Ansseau, Alexandra Belayew, Frédérique Coppée, Anne-Emilie Declèves, Alexandre Legrand
Published 2020-07-01

DUX4c is up-regulated in FSHD. It induces the MYF5 protein and human myoblast proliferation.

by Eugénie Ansseau, Dalila Laoudj-Chenivesse, Aline Marcowycz, Alexandra Tassin, Céline Vanderplanck, Sébastien Sauvage, Marietta Barro, Isabelle Mahieu, Axelle Leroy, India Leclercq, Véronique Mainfroid, Denise Figlewicz, Vincent Mouly, Gillian Butler-Browne, Alexandra Belayew, Frédérique Coppée
Published 2009-10-01

Homologous Transcription Factors DUX4 and DUX4c Associate with Cytoplasmic Proteins during Muscle Differentiation.

by Eugénie Ansseau, Jocelyn O Eidahl, Céline Lancelot, Alexandra Tassin, Christel Matteotti, Cassandre Yip, Jian Liu, Baptiste Leroy, Céline Hubeau, Cécile Gerbaux, Samuel Cloet, Armelle Wauters, Sabrina Zorbo, Pierre Meyer, Isabelle Pirson, Dalila Laoudj-Chenivesse, Ruddy Wattiez, Scott Q Harper, Alexandra Belayew, Frédérique Coppée
Published 2016-01-01