Targeting Cell Entry of Enveloped Viruses as an Antiviral Strategy

by Elodie Teissier, François Penin, Eve-Isabelle Pécheur
Published 2010-12-01

The p7 protein of hepatitis C virus forms structurally plastic, minimalist ion channels.

by Danielle E Chandler, François Penin, Klaus Schulten, Christophe Chipot
Published 2012-01-01

NS2 proteases from hepatitis C virus and related hepaciviruses share composite active sites and previously unrecognized intrinsic proteolytic activities.

by Célia Boukadida, Matthieu Fritz, Brigitte Blumen, Marie-Laure Fogeron, François Penin, Annette Martin
Published 2018-02-01

Hepatitis C virus p7 protein is crucial for assembly and release of infectious virions.

by Eike Steinmann, Francois Penin, Stephanie Kallis, Arvind H Patel, Ralf Bartenschlager, Thomas Pietschmann
Published 2007-07-01

Structural and functional studies of nonstructural protein 2 of the hepatitis C virus reveal its key role as organizer of virion assembly.

by Vlastimil Jirasko, Roland Montserret, Ji Young Lee, Jérôme Gouttenoire, Darius Moradpour, Francois Penin, Ralf Bartenschlager
Published 2010-12-01

Aminoterminal amphipathic α-helix AH1 of hepatitis C virus nonstructural protein 4B possesses a dual role in RNA replication and virus production.

by Jérôme Gouttenoire, Roland Montserret, David Paul, Rosa Castillo, Simon Meister, Ralf Bartenschlager, François Penin, Darius Moradpour
Published 2014-10-01

The amino-terminus of the hepatitis C virus (HCV) p7 viroporin and its cleavage from glycoprotein E2-p7 precursor determine specific infectivity and secretion levels of HCV particl...

by Solène Denolly, Chloé Mialon, Thomas Bourlet, Fouzia Amirache, François Penin, Brett Lindenbach, Bertrand Boson, François-Loïc Cosset
Published 2017-12-01

Secretion of hepatitis C virus envelope glycoproteins depends on assembly of apolipoprotein B positive lipoproteins.

by Vinca Icard, Olivier Diaz, Caroline Scholtes, Laure Perrin-Cocon, Christophe Ramière, Ralf Bartenschlager, Francois Penin, Vincent Lotteau, Patrice André
Published 2009-01-01

NS2 protein of hepatitis C virus interacts with structural and non-structural proteins towards virus assembly.

by Costin-Ioan Popescu, Nathalie Callens, Dave Trinel, Philippe Roingeard, Darius Moradpour, Véronique Descamps, Gilles Duverlie, François Penin, Laurent Héliot, Yves Rouillé, Jean Dubuisson
Published 2011-02-01

The N-terminal Helical Region of the Hepatitis C Virus p7 Ion Channel Protein Is Critical for Infectious Virus Production.

by Margaret A Scull, William M Schneider, Brenna R Flatley, Robert Hayden, Canny Fung, Christopher T Jones, Marieke van de Belt, François Penin, Charles M Rice
Published 2015-11-01

OCIAD1 is a host mitochondrial substrate of the hepatitis C virus NS3-4A protease.

by Huong T L Tran, Kenichi Morikawa, Anggakusuma, Rose Zibi, Viet Loan Dao Thi, François Penin, Markus H Heim, Manfredo Quadroni, Thomas Pietschmann, Jérôme Gouttenoire, Darius Moradpour
Published 2020-01-01

Mechanism of inhibition of enveloped virus membrane fusion by the antiviral drug arbidol.

by Elodie Teissier, Giorgia Zandomeneghi, Antoine Loquet, Dimitri Lavillette, Jean-Pierre Lavergne, Roland Montserret, François-Loïc Cosset, Anja Böckmann, Beat H Meier, François Penin, Eve-Isabelle Pécheur
Published 2011-01-01

The signal peptide of Staphylococcus aureus panton valentine leukocidin LukS component mediates increased adhesion to heparan sulfates.

by Anne Tristan, Yvonne Benito, Roland Montserret, Sandrine Boisset, Eric Dusserre, Francois Penin, Florence Ruggiero, Jerome Etienne, Hugues Lortat-Jacob, Gerard Lina, M Gabriela Bowden, François Vandenesch
Published 2009-01-01

Several Human Liver Cell Expressed Apolipoproteins Complement HCV Virus Production with Varying Efficacy Conferring Differential Specific Infectivity to Released Viruses.

by Kathrin Hueging, Romy Weller, Mandy Doepke, Gabrielle Vieyres, Daniel Todt, Benno Wölk, Florian W R Vondran, Robert Geffers, Chris Lauber, Lars Kaderali, François Penin, Thomas Pietschmann
Published 2015-01-01