Growth condition dependency is the major cause of non-responsiveness upon genetic perturbation.

by Saman Amini, Frank C P Holstege, Patrick Kemmeren
Published 2017-01-01

An Optimized Chromatin Immunoprecipitation Protocol for Quantification of Protein-DNA Interactions

by Wim J. de Jonge, Mariël Brok, Patrick Kemmeren, Frank C.P. Holstege
Published 2020-06-01

High-throughput genetic and gene expression analysis of the RNAPII-CTD reveals unexpected connections to SRB10/CDK8.

by Maria J Aristizabal, Gian Luca Negri, Joris J Benschop, Frank C P Holstege, Nevan J Krogan, Michael S Kobor
Published 2013-08-01

The ability of transcription factors to differentially regulate gene expression is a crucial component of the mechanism underlying inversion, a frequently observed genetic interact...

by Saman Amini, Annika Jacobsen, Olga Ivanova, Philip Lijnzaad, Jaap Heringa, Frank C P Holstege, K Anton Feenstra, Patrick Kemmeren
Published 2019-05-01

Amygdala 14-3-3ζ as a novel modulator of escalating alcohol intake in mice.

by Heidi M B Lesscher, Julia M Houthuijzen, Marian J Groot Koerkamp, Frank C P Holstege, Louk J M J Vanderschuren
Published 2012-01-01

A systematic analysis of genetic interactions and their underlying biology in childhood cancer

by Josephine T. Daub, Saman Amini, Denise J. E. Kersjes, Xiaotu Ma, Natalie Jäger, Jinghui Zhang, Stefan M. Pfister, Frank C. P. Holstege, Patrick Kemmeren
Published 2021-10-01

A barcode screen for epigenetic regulators reveals a role for the NuB4/HAT-B histone acetyltransferase complex in histone turnover.

by Kitty F Verzijlbergen, Tibor van Welsem, Daoud Sie, Tineke L Lenstra, Daniel J Turner, Frank C P Holstege, Ron M Kerkhoven, Fred van Leeuwen
Published 2011-10-01

Genome wide expression profiling of the mesodiencephalic region identifies novel factors involved in early and late dopaminergic development

by Koushik Chakrabarty, Lars Von Oerthel, Anita Hellemons, Frédéric Clotman, Agnès Espana, Marian Groot Koerkamp, Frank C. P. Holstege, R. Jeroen Pasterkamp, Marten P. Smidt
Published 2012-05-01

The role of Ctk1 kinase in termination of small non-coding RNAs.

by Tineke L Lenstra, Agnieszka Tudek, Sandra Clauder, Zhenyu Xu, Spyridon T Pachis, Dik van Leenen, Patrick Kemmeren, Lars M Steinmetz, Domenico Libri, Frank C P Holstege
Published 2013-01-01

Recruitment of TREX to the transcription machinery by its direct binding to the phospho-CTD of RNA polymerase II.

by Dominik M Meinel, Cornelia Burkert-Kautzsch, Anja Kieser, Eoghan O'Duibhir, Matthias Siebert, Andreas Mayer, Patrick Cramer, Johannes Söding, Frank C P Holstege, Katja Sträßer
Published 2013-11-01

Two distinct repressive mechanisms for histone 3 lysine 4 methylation through promoting 3'-end antisense transcription.

by Thanasis Margaritis, Vincent Oreal, Nathalie Brabers, Laetitia Maestroni, Adeline Vitaliano-Prunier, Joris J Benschop, Sander van Hooff, Dik van Leenen, Catherine Dargemont, Vincent Géli, Frank C P Holstege
Published 2012-09-01

Caenorhabditis elegans cyclin D/CDK4 and cyclin E/CDK2 induce distinct cell cycle re-entry programs in differentiated muscle cells.

by Jerome Korzelius, Inge The, Suzan Ruijtenberg, Martine B W Prinsen, Vincent Portegijs, Teije C Middelkoop, Marian J Groot Koerkamp, Frank C P Holstege, Mike Boxem, Sander van den Heuvel
Published 2011-11-01

Balancing of Histone H3K4 Methylation States by the Kdm5c/SMCX Histone Demethylase Modulates Promoter and Enhancer Function

by Nikolay S. Outchkourov, Jose M. Muiño, Kerstin Kaufmann, Wilfred F.J. van IJcken, Marian J. Groot Koerkamp, Dik van Leenen, Petra de Graaf, Frank C.P. Holstege, Frank G. Grosveld, H.T. Marc Timmers
Published 2013-04-01

The genomic landscape of compensatory evolution.

by Béla Szamecz, Gábor Boross, Dorottya Kalapis, Károly Kovács, Gergely Fekete, Zoltán Farkas, Viktória Lázár, Mónika Hrtyan, Patrick Kemmeren, Marian J A Groot Koerkamp, Edit Rutkai, Frank C P Holstege, Balázs Papp, Csaba Pál
Published 2014-08-01

Aberrant expression and distribution of enzymes of the urea cycle and other ammonia metabolizing pathways in dogs with congenital portosystemic shunts.

by Giora van Straten, Frank G van Steenbeek, Guy C M Grinwis, Robert P Favier, Anne Kummeling, Ingrid H van Gils, Hille Fieten, Marian J A Groot Koerkamp, Frank C P Holstege, Jan Rothuizen, Bart Spee
Published 2014-01-01

Altered subcellular localization of heat shock protein 90 is associated with impaired expression of the aryl hydrocarbon receptor pathway in dogs.

by Frank G van Steenbeek, Bart Spee, Louis C Penning, Anne Kummeling, Ingrid H M van Gils, Guy C M Grinwis, Dik Van Leenen, Frank C P Holstege, Manon Vos-Loohuis, Jan Rothuizen, Peter A J Leegwater
Published 2013-01-01

PDGFRB Promotes Liver Metastasis Formation of Mesenchymal-Like Colorectal Tumor Cells

by Ernst J.A. Steller, Danielle A. Raats, Jan Koster, Bert Rutten, Klaas M. Govaert, Benjamin L. Emmink, Nikol Snoeren, Sander R. van Hooff, Frank C.P. Holstege, Coen Maas, Rinkes Inne H.M. Borel, Onno Kranenburg
Published 2013-02-01

Centromere binding and a conserved role in chromosome stability for SUMO-dependent ubiquitin ligases.

by Loes A L van de Pasch, Antony J Miles, Wilco Nijenhuis, Nathalie A C H Brabers, Dik van Leenen, Philip Lijnzaad, Markus K Brown, Jimmy Ouellet, Yves Barral, Geert J P L Kops, Frank C P Holstege
Published 2013-01-01

Systematic Triple-Mutant Analysis Uncovers Functional Connectivity between Pathways Involved in Chromosome Regulation

by James E. Haber, Hannes Braberg, Qiuqin Wu, Richard Alexander, Julian Haase, Colm Ryan, Zach Lipkin-Moore, Kathleen E. Franks-Skiba, Tasha Johnson, Michael Shales, Tineke L. Lenstra, Frank C.P. Holstege, Jeffrey R. Johnson, Kerry Bloom, Nevan J. Krogan
Published 2013-06-01

Expression Profiling after Prolonged Experimental Febrile Seizures in Mice Suggests Structural Remodeling in the Hippocampus.

by Bart C Jongbloets, Koen L I van Gassen, Anne A Kan, Anneke H O Olde Engberink, Marina de Wit, Inge G Wolterink-Donselaar, Marian J A Groot Koerkamp, Onno van Nieuwenhuizen, Frank C P Holstege, Pierre N E de Graan
Published 2015-01-01