Massive autophosphorylation of the Ser/Thr-rich domain controls protein kinase activity of TRPM6 and TRPM7.

by Kristopher Clark, Jeroen Middelbeek, Nick A Morrice, Carl G Figdor, Edwin Lasonder, Frank N van Leeuwen
Published 2008-03-01

Creatine kinase-mediated ATP supply fuels actin-based events in phagocytosis.

by Jan W P Kuiper, Helma Pluk, Frank Oerlemans, Frank N van Leeuwen, Frank de Lange, Jack Fransen, Bé Wieringa
Published 2008-03-01

Targeted Deletion of Btg1 and Btg2 Results in Homeotic Transformation of the Axial Skeleton.

by Esther Tijchon, Dorette van Ingen Schenau, Fred van Opzeeland, Felice Tirone, Peter M Hoogerbrugge, Frank N Van Leeuwen, Blanca Scheijen
Published 2015-01-01

The origin and nature of tightly clustered BTG1 deletions in precursor B-cell acute lymphoblastic leukemia support a model of multiclonal evolution.

by Esmé Waanders, Blanca Scheijen, Laurens T van der Meer, Simon V van Reijmersdal, Liesbeth van Emst, Yvet Kroeze, Edwin Sonneveld, Peter M Hoogerbrugge, Ad Geurts van Kessel, Frank N van Leeuwen, Roland P Kuiper
Published 2012-01-01

Upfront Treatment Influences the Composition of Genetic Alterations in Relapsed Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia

by Jiangyan Yu, Esmé Waanders, Simon V. van Reijmersdal, Željko Antić, Charlotte M. van Bosbeek, Edwin Sonneveld, Hester de Groot, Marta Fiocco, Ad Geurts van Kessel, Frank N. van Leeuwen, Rob Pieters, Peter M. Hoogerbrugge, Roland P. Kuiper
Published 2020-02-01

Influence of genetic variants in TPMT and COMT associated with cisplatin induced hearing loss in patients with cancer: two new cohorts and a meta-analysis reveal significant hetero...

by Melanie M Hagleitner, Marieke J H Coenen, Ana Patino-Garcia, Eveline S J M de Bont, Anna Gonzalez-Neira, Hanneke I Vos, Frank N van Leeuwen, Hans Gelderblom, Peter M Hoogerbrugge, Henk-Jan Guchelaar, Maroeska W M Te Loo
Published 2014-01-01

Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.

by Gordan Lauc, Jennifer E Huffman, Maja Pučić, Lina Zgaga, Barbara Adamczyk, Ana Mužinić, Mislav Novokmet, Ozren Polašek, Olga Gornik, Jasminka Krištić, Toma Keser, Veronique Vitart, Blanca Scheijen, Hae-Won Uh, Mariam Molokhia, Alan Leslie Patrick, Paul McKeigue, Ivana Kolčić, Ivan Krešimir Lukić, Olivia Swann, Frank N van Leeuwen, L Renee Ruhaak, Jeanine J Houwing-Duistermaat, P Eline Slagboom, Marian Beekman, Anton J M de Craen, André M Deelder, Qiang Zeng, Wei Wang, Nicholas D Hastie, Ulf Gyllensten, James F Wilson, Manfred Wuhrer, Alan F Wright, Pauline M Rudd, Caroline Hayward, Yurii Aulchenko, Harry Campbell, Igor Rudan
Published 2013-01-01