Signal loss due to oligomerization in ELISA analysis of amyloid-beta can be recovered by a novel sample pre-treatment method

by Leen Janssen, Frank Sobott, Peter P. De Deyn, Debby Van Dam
Published 2015-01-01

Analysis of the PcrA-RNA polymerase complex reveals a helicase interaction motif and a role for PcrA/UvrD helicase in the suppression of R-loops

by Inigo Urrutia-Irazabal, James R Ault, Frank Sobott, Nigel J Savery, Mark S Dillingham
Published 2021-07-01

Structural mechanism of synergistic activation of Aurora kinase B/C by phosphorylated INCENP

by Kamal R. Abdul Azeez, Sneha Chatterjee, Channing Yu, Todd R. Golub, Frank Sobott, Jonathan M. Elkins
Published 2019-07-01

Effects of Detergent on α-Synuclein Structure. A Native MS-Ion Mobility Study

by Rani Moons, Renate van der Wekken-de Bruijne, Stuart Maudsley, Filip Lemière, Anne-Marie Lambeir, Frank Sobott
Published 2020-10-01

A dual role in regulation and toxicity for the disordered N-terminus of the toxin GraT

by Ariel Talavera, Hedvig Tamman, Andres Ainelo, Albert Konijnenberg, San Hadži, Frank Sobott, Abel Garcia-Pino, Rita Hõrak, Remy Loris
Published 2019-02-01

Profiling Dopamine-Induced Oxidized Proteoforms of β-synuclein by Top-Down Mass Spectrometry

by Arianna Luise, Elena De Cecco, Erika Ponzini, Martina Sollazzo, PierLuigi Mauri, Frank Sobott, Giuseppe Legname, Rita Grandori, Carlo Santambrogio
Published 2021-06-01

Cryo-EM structure of human mitochondrial HSPD1

by David P. Klebl, Matthew C. Feasey, Emma L. Hesketh, Neil A. Ranson, Heiko Wurdak, Frank Sobott, Robin S. Bon, Stephen P. Muench
Published 2021-01-01

A cryo-EM grid preparation device for time-resolved structural studies

by Dimitrios Kontziampasis, David P. Klebl, Matthew G. Iadanza, Charlotte A. Scarff, Florian Kopf, Frank Sobott, Diana C. F. Monteiro, Martin Trebbin, Stephen P. Muench, Howard D. White
Published 2019-11-01

The effect of reactive oxygen and nitrogen species on the structure of cytoglobin: A potential tumor suppressor

by Joey De Backer, Jamoliddin Razzokov, Dietmar Hammerschmid, Carl Mensch, Zainab Hafideddine, Naresh Kumar, Geert van Raemdonck, Maksudbek Yusupov, Sabine Van Doorslaer, Christian Johannessen, Frank Sobott, Annemie Bogaerts, Sylvia Dewilde
Published 2018-10-01

Structural modeling of a novel membrane-bound globin-coupled sensor in Geobacter sulfurreducens

by Dietmar Hammerschmid, Francesca Germani, Salvador I. Drusin, Charline Fagnen, Claudio D. Schuster, David Hoogewijs, Marcelo A. Marti, Catherine Venien-Bryan, Luc Moens, Sabine Van Doorslaer, Frank Sobott, Sylvia Dewilde
Published 2021-01-01

The structural basis for dynamic DNA binding and bridging interactions which condense the bacterial centromere

by Gemma LM Fisher, César L Pastrana, Victoria A Higman, Alan Koh, James A Taylor, Annika Butterer, Timothy Craggs, Frank Sobott, Heath Murray, Matthew P Crump, Fernando Moreno-Herrero, Mark S Dillingham
Published 2017-12-01

Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity

by Amberley D. Stephens, Maria Zacharopoulou, Rani Moons, Giuliana Fusco, Neeleema Seetaloo, Anass Chiki, Philippa J. Woodhams, Ioanna Mela, Hilal A. Lashuel, Jonathan J. Phillips, Alfonso De Simone, Frank Sobott, Gabriele S. Kaminski Schierle
Published 2020-06-01

Structure of the endocytic adaptor complex reveals the basis for efficient membrane anchoring during clathrin-mediated endocytosis

by Javier Lizarrondo, David P. Klebl, Stephan Niebling, Marc Abella, Martin A. Schroer, Haydyn D. T. Mertens, Katharina Veith, Roland Thuenauer, Dmitri I. Svergun, Michal Skruzny, Frank Sobott, Stephen P. Muench, Maria M. Garcia-Alai
Published 2021-05-01

A homologue of the Parkinson’s disease-associated protein LRRK2 undergoes a monomer-dimer transition during GTP turnover

by Egon Deyaert, Lina Wauters, Giambattista Guaitoli, Albert Konijnenberg, Margaux Leemans, Susanne Terheyden, Arsen Petrovic, Rodrigo Gallardo, Laura M. Nederveen-Schippers, Panagiotis S. Athanasopoulos, Henderikus Pots, Peter J. M. Van Haastert, Frank Sobott, Christian Johannes Gloeckner, Rouslan Efremov, Arjan Kortholt, Wim Versées
Published 2017-10-01