Nanobody-Based Biologics for Modulating Purinergic Signaling in Inflammation and Immunity

by Stephan Menzel, Nicole Schwarz, Friedrich Haag, Friedrich Koch-Nolte
Published 2018-03-01

T Cells of Different Developmental Stages Differ in Sensitivity to Apoptosis Induced by Extracellular NAD

by Friedrich Haag, Dunja Freese, Felix Scheublein, Wiebke Ohlrogge, Sahil Adriouch, Michel Seman, Friedrich Koch-Nolte
Published 2002-01-01

ADP-Ribosylation Regulates the Signaling Function of IFN-γ

by Stephan Menzel, Tomas Koudelka, Björn Rissiek, Friedrich Haag, Catherine Meyer-Schwesinger, Andreas Tholey, Friedrich Koch-Nolte
Published 2021-03-01

Daratumumab and Nanobody-Based Heavy Chain Antibodies Inhibit the ADPR Cyclase but not the NAD⁺ Hydrolase Activity of CD38-Expressing Multiple Myeloma Cells

by Natalie Baum, Ralf Fliegert, Andreas Bauche, Julia Hambach, Stephan Menzel, Friedrich Haag, Peter Bannas, Friedrich Koch-Nolte
Published 2021-12-01

CD83 modulates B cell function in vitro: increased IL-10 and reduced Ig secretion by CD83Tg B cells.

by Birte Kretschmer, Katja Lüthje, Andreas H Guse, Svenja Ehrlich, Friedrich Koch-Nolte, Friedrich Haag, Bernhard Fleischer, Minka Breloer
Published 2007-08-01

Generation and Function of Non-cell-bound CD73 in Inflammation

by Enja Schneider, Anne Rissiek, Riekje Winzer, Berta Puig, Björn Rissiek, Friedrich Haag, Hans-Willi Mittrücker, Tim Magnus, Eva Tolosa
Published 2019-07-01

Alternative splicing of the N-terminal cytosolic and transmembrane domains of P2X7 controls gating of the ion channel by ADP-ribosylation.

by Nicole Schwarz, Laurent Drouot, Annette Nicke, Ralf Fliegert, Olivier Boyer, Andreas H Guse, Friedrich Haag, Sahil Adriouch, Friedrich Koch-Nolte
Published 2012-01-01

A cDNA Immunization Strategy to Generate Nanobodies against Membrane Proteins in Native Conformation

by Thomas Eden, Stephan Menzel, Janusz Wesolowski, Philine Bergmann, Marion Nissen, Gudrun Dubberke, Fabienne Seyfried, Birte Albrecht, Friedrich Haag, Friedrich Koch-Nolte
Published 2018-01-01

CD39 is upregulated during activation of mouse and human T cells and attenuates the immune response to Listeria monocytogenes.

by Friederike Raczkowski, Anne Rissiek, Isabell Ricklefs, Kirsten Heiss, Valéa Schumacher, Kira Wundenberg, Friedrich Haag, Friedrich Koch-Nolte, Eva Tolosa, Hans-Willi Mittrücker
Published 2018-01-01

Quantitative Magnetic Resonance Imaging of Enzyme Activity on the Cell Surface: In Vitro and In Vivo Monitoring of ADP-Ribosyltransferase 2 on T Cells

by Peter Bannas, Oliver Graumann, Philipp Balcerak, Kersten Peldschus, Michael Gerhard Kaul, Heinrich Hohenberg, Friedrich Haag, Gerhard Adam, Harald Ittrich, Friedrich Koch-Nolte
Published 2010-07-01

Defining the CD39/CD73 Axis in SARS-CoV-2 Infection: The CD73^- Phenotype Identifies Polyfunctional Cytotoxic Lymphocytes

by Parimah Ahmadi, Philip Hartjen, Matin Kohsar, Silke Kummer, Stefan Schmiedel, Jan-Hendrik Bockmann, Anahita Fathi, Samuel Huber, Friedrich Haag, Julian Schulze zur Wiesch
Published 2020-07-01

Evaluation of P2X7 Receptor Function in Tumor Contexts Using rAAV Vector and Nanobodies (AAVnano)

by Mélanie Demeules, Allan Scarpitta, Catalina Abad, Henri Gondé, Romain Hardet, Carolina Pinto-Espinoza, Anna Marei Eichhoff, Waldemar Schäfer, Friedrich Haag, Friedrich Koch-Nolte, Sahil Adriouch
Published 2020-09-01

Nanobody-Enhanced Targeting of AAV Gene Therapy Vectors

by Anna Marei Eichhoff, Kathleen Börner, Birte Albrecht, Waldemar Schäfer, Natalie Baum, Friedrich Haag, Jakob Körbelin, Martin Trepel, Ingke Braren, Dirk Grimm, Sahil Adriouch, Friedrich Koch-Nolte
Published 2019-12-01

A simple, sensitive, and low‐cost FACS assay for detecting antibodies against the native SARS‐CoV‐2 spike protein

by Julia Hambach, Tobias Stähler, Thomas Eden, Dorte Wendt, Natalie Tode, Friedrich Haag, Eva Tolosa, Marcus Altfeld, Anahita Fathi, Christine Dahlke, Marylyn M. Addo, Stephan Menzel, Friedrich Koch‐Nolte
Published 2021-09-01

Longitudinal Analysis of Tetanus- and Influenza-Specific IgG Antibodies in Myeloma Patients

by Sebastian Kobold, Tim Luetkens, Britta Marlen Bartels, Yanran Cao, York Hildebrandt, Orhan Sezer, Henrike Reinhard, Julia Templin, Katrin Bartels, Nesrine Lajmi, Friedrich Haag, Carsten Bokemeyer, Nicolaus Kröger, Djordje Atanackovic
Published 2012-01-01

Ecto-ADP-ribosyltransferase ARTC2.1 functionally modulates FcγR1 and FcγR2B on murine microglia

by Björn Rissiek, Stephan Menzel, Mario Leutert, Maike Cordes, Sarah Behr, Larissa Jank, Peter Ludewig, Mathias Gelderblom, Anne Rissiek, Sahil Adriouch, Friedrich Haag, Michael O. Hottiger, Friedrich Koch-Nolte, Tim Magnus
Published 2017-11-01

Significance of Anti-Nuclear Antibodies and Cryoglobulins in Patients with Acute and Chronic HEV Infection

by Thomas Horvatits, Julian Schulze zur Wiesch, Susanne Polywka, Gustav Buescher, Marc Lütgehetmann, Elaine Hussey, Karoline Horvatits, Sven Peine, Friedrich Haag, Marylyn M. Addo, Ansgar W. Lohse, Christina Weiler-Normann, Sven Pischke
Published 2020-09-01

Mouse CD38-Specific Heavy Chain Antibodies Inhibit CD38 GDPR-Cyclase Activity and Mediate Cytotoxicity Against Tumor Cells

by Natalie Baum, Marie Eggers, Julia Koenigsdorf, Julia Koenigsdorf, Stephan Menzel, Stephan Menzel, Julia Hambach, Julia Hambach, Tobias Staehler, Ralf Fliegert, Frederike Kulow, Gerhard Adam, Friedrich Haag, Peter Bannas, Friedrich Koch-Nolte
Published 2021-09-01

Patients with Multiple Myeloma Develop SOX2-Specific Autoantibodies after Allogeneic Stem Cell Transplantation

by Sebastian Kobold, Sinje Tams, Tim Luetkens, Yanran Cao, Orhan Sezer, Britta Marlen Bartels, Henrike Reinhard, Julia Templin, Katrin Bartels, York Hildebrandt, Nesrine Lajmi, Andreas Marx, Friedrich Haag, Carsten Bokemeyer, Nicolaus Kröger, Djordje Atanackovic
Published 2011-01-01

Targeting CD38-Expressing Multiple Myeloma and Burkitt Lymphoma Cells In Vitro with Nanobody-Based Chimeric Antigen Receptors (Nb-CARs)

by Julia Hambach, Kristoffer Riecken, Sophia Cichutek, Kerstin Schütze, Birte Albrecht, Katharina Petry, Jana Larissa Röckendorf, Natalie Baum, Nicolaus Kröger, Timon Hansen, Gunter Schuch, Friedrich Haag, Gerhard Adam, Boris Fehse, Peter Bannas, Friedrich Koch-Nolte
Published 2020-01-01