High cell-surface density of HER2 deforms cell membranes

by Inhee Chung, Mike Reichelt, Lily Shao, Robert W. Akita, Hartmut Koeppen, Linda Rangell, Gabriele Schaefer, Ira Mellman, Mark X. Sliwkowski
Published 2016-09-01

Reorienting the Fab domains of trastuzumab results in potent HER2 activators.

by Justin M Scheer, Wendy Sandoval, J Michael Elliott, Lily Shao, Elizabeth Luis, Sock-Cheng Lewin-Koh, Gabriele Schaefer, Richard Vandlen
Published 2012-01-01

Clinical responses to ERK inhibition in BRAF V600E-mutant colorectal cancer predicted using a computational model

by Daniel C. Kirouac, Gabriele Schaefer, Jocelyn Chan, Mark Merchant, Christine Orr, Shih-Min A. Huang, John Moffat, Lichuan Liu, Kapil Gadkar, Saroja Ramanujan
Published 2017-06-01

NRG1 is a critical regulator of differentiation in TP63-driven squamous cell carcinoma

by Ganapati V Hegde, Cecile de la Cruz, Jennifer M Giltnane, Lisa Crocker, Avinashnarayan Venkatanarayan, Gabriele Schaefer, Debra Dunlap, Joerg D Hoeck, Robert Piskol, Florian Gnad, Zora Modrusan, Frederic J de Sauvage, Christian W Siebel, Erica L Jackson
Published 2019-05-01

Correction: Combined MEK and ERK inhibition overcomes therapy-mediated pathway reactivation in RAS mutant tumors.

by Mark Merchant, John Moffat, Gabriele Schaefer, Jocelyn Chan, Xi Wang, Christine Orr, Jason Cheng, Thomas Hunsaker, Lily Shao, Stephanie J Wang, Marie-Claire Wagle, Eva Lin, Peter M Haverty, Sheerin Shahidi-Latham, Hai Ngu, Margaret Solon, Jeffrey Eastham-Anderson, Hartmut Koeppen, Shih-Min A Huang, Jacob Schwarz, Marcia Belvin, Daniel Kirouac, Melissa R Junttila
Published 2018-01-01

Combined MEK and ERK inhibition overcomes therapy-mediated pathway reactivation in RAS mutant tumors.

by Mark Merchant, John Moffat, Gabriele Schaefer, Jocelyn Chan, Xi Wang, Christine Orr, Jason Cheng, Thomas Hunsaker, Lily Shao, Stephanie J Wang, Marie-Claire Wagle, Eva Lin, Peter M Haverty, Sheerin Shahidi-Latham, Hai Ngu, Margaret Solon, Jeffrey Eastham-Anderson, Hartmut Koeppen, Shih-Min A Huang, Jacob Schwarz, Marcia Belvin, Daniel Kirouac, Melissa R Junttila
Published 2017-01-01