RIG-I-like receptor-induced IRF3 mediated pathway of apoptosis (RIPA): a new antiviral pathway

by Saurabh Chattopadhyay, Ganes C. Sen
Published 2016-11-01

Innate Immune Responses to Herpesvirus Infection

by Christine M. O’Connor, Ganes C. Sen
Published 2021-08-01

The Human dsRNA binding protein PACT is unable to functionally substitute for the Drosophila dsRNA binding protein R2D2 [v1; ref status: indexed, http://f1000r.es/201]

by Benjamin K Dickerman, Jocelyn A McDonald, Ganes C Sen
Published 2013-10-01

The Human dsRNA binding protein PACT is unable to functionally substitute for the Drosophila dsRNA binding protein R2D2 [v2; ref status: indexed, http://f1000r.es/352]

by Benjamin K Dickerman, Jocelyn A McDonald, Ganes C Sen
Published 2014-03-01

Biphasic and cardiomyocyte-specific IFIT activity protects cardiomyocytes from enteroviral infection.

by Taishi Kimura, Claudia T Flynn, Mehrdad Alirezaei, Ganes C Sen, J Lindsay Whitton
Published 2019-04-01

Induction of interferon-stimulated genes by IRF3 promotes replication of Toxoplasma gondii.

by Tanmay Majumdar, Saurabh Chattopadhyay, Evgeny Ozhegov, Jayeeta Dhar, Ramansu Goswami, Ganes C Sen, Sailen Barik
Published 2015-03-01

Tissue-specific expression of transgenic secreted ACE in vasculature can restore normal kidney functions, but not blood pressure, of Ace-/- mice.

by Saurabh Chattopadhyay, Sean P Kessler, Juliana Almada Colucci, Michifumi Yamashita, Preenie deS Senanayake, Ganes C Sen
Published 2014-01-01

A new mechanism of interferon's antiviral action: Induction of autophagy, essential for paramyxovirus replication, is inhibited by the interferon stimulated gene, TDRD7.

by Gayatri Subramanian, Teodora Kuzmanovic, Ying Zhang, Cara Beate Peter, Manoj Veleeparambil, Ritu Chakravarti, Ganes C Sen, Saurabh Chattopadhyay
Published 2018-01-01

The protein kinase double-stranded RNA-dependent (PKR) enhances protection against disease cause by a non-viral pathogen.

by Pauline Sebby Ogolla, Jose-Andres C Portillo, Christine L White, Krupen Patel, Bruce Lamb, Ganes C Sen, Carlos S Subauste
Published 2013-01-01

Ifit2 deficiency restricts microglial activation and leukocyte migration following murine coronavirus (m-CoV) CNS infection.

by Jayasri Das Sarma, Amy Burrows, Patricia Rayman, Mi-Hyun Hwang, Soumya Kundu, Nikhil Sharma, Cornelia Bergmann, Ganes C Sen
Published 2020-11-01

Missense mutation in the second RNA binding domain reveals a role for Prkra (PACT/RAX) during skull development.

by Benjamin K Dickerman, Christine L White, Claire Chevalier, Valérie Nalesso, Cyril Charles, Sophie Fouchécourt, Florian Guillou, Laurent Viriot, Ganes C Sen, Yann Hérault
Published 2011-01-01

Interferon-induced Ifit2/ISG54 protects mice from lethal VSV neuropathogenesis.

by Volker Fensterl, Jaime L Wetzel, Srividya Ramachandran, Tomoaki Ogino, Stephen A Stohlman, Cornelia C Bergmann, Michael S Diamond, Herbert W Virgin, Ganes C Sen
Published 2012-01-01

2'-O methylation of the viral mRNA cap by West Nile virus evades ifit1-dependent and -independent mechanisms of host restriction in vivo.

by Kristy J Szretter, Brian P Daniels, Hyelim Cho, Maria D Gainey, Wayne M Yokoyama, Michael Gale, Herbert W Virgin, Robyn S Klein, Ganes C Sen, Michael S Diamond
Published 2012-01-01

DJ-1-Nrf2 axis is activated upon murine β-coronavirus infection in the CNS

by Soumya Kundu, Fareeha Saadi, Sourodip Sengupta, Gisha Rose Antony, Vineeth A. Raveendran, Rahul Kumar, Mithila Ashok Kamble, Lucky Sarkar, Amy Burrows, Debnath Pal, Ganes C. Sen, Jayasri Das Sarma
Published 2021-12-01

Inflammation mobilizes copper metabolism to promote colon tumorigenesis via an IL-17-STEAP4-XIAP axis

by Yun Liao, Junjie Zhao, Katarzyna Bulek, Fangqiang Tang, Xing Chen, Gang Cai, Shang Jia, Paul L. Fox, Emina Huang, Theresa T. Pizarro, Matthew F. Kalady, Mark W. Jackson, Shideng Bao, Ganes C. Sen, George R. Stark, Christopher J. Chang, Xiaoxia Li
Published 2020-02-01

PACT-mediated PKR activation acts as a hyperosmotic stress intensity sensor weakening osmoadaptation and enhancing inflammation

by Kenneth T Farabaugh, Dawid Krokowski, Bo-Jhih Guan, Zhaofeng Gao, Xing-Huang Gao, Jing Wu, Raul Jobava, Greeshma Ray, Tristan J de Jesus, Massimiliano G Bianchi, Evelyn Chukwurah, Ovidio Bussolati, Michael Kilberg, David A Buchner, Ganes C Sen, Calvin Cotton, Christine McDonald, Michelle Longworth, Parameswaran Ramakrishnan, Maria Hatzoglou
Published 2020-03-01