C-Terminal Auto-Regulatory Motif of Hepatitis C Virus NS5B Interacts with Human VAPB-MSP to Form a Dynamic Replication Complex.

by Garvita Gupta, Jianxing Song
Published 2016-01-01

Intrinsically unstructured domain 3 of hepatitis C Virus NS5A forms a "fuzzy complex" with VAPB-MSP domain which carries ALS-causing mutations.

by Garvita Gupta, Haina Qin, Jianxing Song
Published 2012-01-01

NMR and MD Studies Reveal That the Isolated Dengue NS3 Protease Is an Intrinsically Disordered Chymotrypsin Fold Which Absolutely Requests NS2B for Correct Folding and Functional D...

by Garvita Gupta, Liangzhong Lim, Jianxing Song
Published 2015-01-01

Resolving the paradox for protein aggregation diseases: a common mechanism for aggregated proteins to initially attack membranes without needing aggregates [v1; ref status: indexed...

by Haina Qin, Liangzhong Lim, Yuanyuan Wei, Garvita Gupta, Jianxing Song
Published 2013-10-01

Resolving the paradox for protein aggregation diseases: NMR structure and dynamics of the membrane-embedded P56S-MSP causing ALS imply a common mechanism for aggregation-prone prot...

by Haina Qin, Liangzhong Lim, Yuanyuan Wei, Garvita Gupta, Jianxing Song
Published 2014-07-01

Structural, stability, dynamic and binding properties of the ALS-causing T46I mutant of the hVAPB MSP domain as revealed by NMR and MD simulations.

by Shixiong Lua, Haina Qin, Liangzhong Lim, Jiahai Shi, Garvita Gupta, Jianxing Song
Published 2011-01-01

VAPC, an human endogenous inhibitor for hepatitis C virus (HCV) infection, is intrinsically unstructured but forms a "fuzzy complex" with HCV NS5B.

by Shaveta Goyal, Garvita Gupta, Haina Qin, Megha Haridas Upadya, Yee Joo Tan, Vincent T K Chow, Jianxing Song
Published 2012-01-01