Sequential forward and reverse transport of the Na+ Ca2+ exchanger generates Ca2+ oscillations within mitochondria

by Krishna Samanta, Gary R. Mirams, Anant B. Parekh
Published 2018-01-01

Ca2+ Channel Re-localization to Plasma-Membrane Microdomains Strengthens Activation of Ca2+-Dependent Nuclear Gene Expression

by Krishna Samanta, Pulak Kar, Gary R. Mirams, Anant B. Parekh
Published 2015-07-01

Selective recruitment of different Ca2+-dependent transcription factors by STIM1-Orai1 channel clusters

by Yu-Ping Lin, Daniel Bakowski, Gary R. Mirams, Anant B. Parekh
Published 2019-06-01

Hierarchical Bayesian inference for ion channel screening dose-response data [version 2; referees: 2 approved]

by Ross H Johnstone, Rémi Bardenet, David J Gavaghan, Gary R Mirams
Published 2017-03-01

Neural Network Differential Equations For Ion Channel Modelling

by Chon Lok Lei, Chon Lok Lei, Chon Lok Lei, Gary R. Mirams
Published 2021-08-01

Immediate and Delayed Response of Simulated Human Atrial Myocytes to Clinically-Relevant Hypokalemia

by Michael Clerx, Gary R. Mirams, Albert J. Rogers, Sanjiv M. Narayan, Wayne R. Giles
Published 2021-05-01

mRNA expression levels in failing human hearts predict cellular electrophysiological remodeling: a population-based simulation study.

by John Walmsley, Jose F Rodriguez, Gary R Mirams, Kevin Burrage, Igor R Efimov, Blanca Rodriguez
Published 2013-01-01

Probabilistic Inference on Noisy Time Series (PINTS)

by Michael Clerx, Martin Robinson, Ben Lambert, Chon Lok Lei, Sanmitra Ghosh, Gary R. Mirams, David J. Gavaghan
Published 2019-07-01

Cardiac TdP risk stratification modelling of anti-infective compounds including chloroquine and hydroxychloroquine

by Dominic G. Whittaker, Rebecca A. Capel, Maurice Hendrix, Xin Hui S. Chan, Neil Herring, Nicholas J. White, Gary R. Mirams, Rebecca-Ann B. Burton
Published 2021-04-01

Use of Patient Health Records to Quantify Drug-Related Pro-arrhythmic Risk

by Mark R. Davies, Michael Martinec, Robert Walls, Roman Schwarz, Gary R. Mirams, Ken Wang, Guido Steiner, Andy Surinach, Carlos Flores, Thierry Lavé, Thomas Singer, Liudmila Polonchuk
Published 2020-08-01

Uncertainty Quantification Reveals the Importance of Data Variability and Experimental Design Considerations for in Silico Proarrhythmia Risk Assessment

by Kelly C. Chang, Sara Dutta, Gary R. Mirams, Kylie A. Beattie, Jiansong Sheng, Phu N. Tran, Min Wu, Wendy W. Wu, Thomas Colatsky, David G. Strauss, Zhihua Li
Published 2017-11-01

Tailoring Mathematical Models to Stem-Cell Derived Cardiomyocyte Lines Can Improve Predictions of Drug-Induced Changes to Their Electrophysiology

by Chon Lok Lei, Ken Wang, Michael Clerx, Ross H. Johnstone, Maria P. Hortigon-Vinagre, Victor Zamora, Andrew Allan, Godfrey L. Smith, David J. Gavaghan, Gary R. Mirams, Liudmila Polonchuk
Published 2017-12-01

Chaste: an open source C++ library for computational physiology and biology.

by Gary R Mirams, Christopher J Arthurs, Miguel O Bernabeu, Rafel Bordas, Jonathan Cooper, Alberto Corrias, Yohan Davit, Sara-Jane Dunn, Alexander G Fletcher, Daniel G Harvey, Megan E Marsh, James M Osborne, Pras Pathmanathan, Joe Pitt-Francis, James Southern, Nejib Zemzemi, David J Gavaghan
Published 2013-01-01

Ten simple rules for effective computational research.

by James M Osborne, Miguel O Bernabeu, Maria Bruna, Ben Calderhead, Jonathan Cooper, Neil Dalchau, Sara-Jane Dunn, Alexander G Fletcher, Robin Freeman, Derek Groen, Bernhard Knapp, Greg J McInerny, Gary R Mirams, Joe Pitt-Francis, Biswa Sengupta, David W Wright, Christian A Yates, David J Gavaghan, Stephen Emmott, Charlotte Deane
Published 2014-03-01