Direct Inhibition of Cellular Fatty Acid Synthase Impairs Replication of Respiratory Syncytial Virus and Other Respiratory Viruses.

by Yamini M Ohol, Zhaoti Wang, George Kemble, Gregory Duke
Published 2015-01-01

FASN Inhibition and Taxane Treatment Combine to Enhance Anti-tumor Efficacy in Diverse Xenograft Tumor Models through Disruption of Tubulin Palmitoylation and Microtubule Organizat...

by Timothy S. Heuer, Richard Ventura, Kasia Mordec, Julie Lai, Marina Fridlib, Douglas Buckley, George Kemble
Published 2017-02-01

H5N1 vaccine-specific B cell responses in ferrets primed with live attenuated seasonal influenza vaccines.

by Xing Cheng, Michael Eisenbraun, Qi Xu, Helen Zhou, Deepali Kulkarni, Kanta Subbarao, George Kemble, Hong Jin
Published 2009-01-01

Inhibition of de novo Palmitate Synthesis by Fatty Acid Synthase Induces Apoptosis in Tumor Cells by Remodeling Cell Membranes, Inhibiting Signaling Pathways, and Reprogramming Gen...

by Richard Ventura, Kasia Mordec, Joanna Waszczuk, Zhaoti Wang, Julie Lai, Marina Fridlib, Douglas Buckley, George Kemble, Timothy S. Heuer
Published 2015-08-01

Safety and immunogenicity following administration of a live, attenuated monovalent 2009 H1N1 influenza vaccine to children and adults in two randomized controlled trials.

by Raburn M Mallory, Elissa Malkin, Christopher S Ambrose, Terramika Bellamy, Li Shi, Tingting Yi, Taff Jones, George Kemble, Filip Dubovsky
Published 2010-10-01

Live, attenuated influenza A H5N1 candidate vaccines provide broad cross-protection in mice and ferrets.

by Amorsolo L Suguitan, Josephine McAuliffe, Kimberly L Mills, Hong Jin, Greg Duke, Bin Lu, Catherine J Luke, Brian Murphy, David E Swayne, George Kemble, Kanta Subbarao
Published 2006-09-01

First-in-human study of the safety, pharmacokinetics, and pharmacodynamics of first-in-class fatty acid synthase inhibitor TVB-2640 alone and with a taxane in advanced tumors

by Gerald Falchook, Jeffrey Infante, Hendrik-Tobias Arkenau, Manish R. Patel, Emma Dean, Erkut Borazanci, Andrew Brenner, Natalie Cook, Juanita Lopez, Shubham Pant, Arthur Frankel, Peter Schmid, Kathleen Moore, William McCulloch, Katharine Grimmer, Marie O'Farrell, George Kemble, Howard Burris
Published 2021-04-01