Decreased TNF Levels and Improved Retinal Ganglion Cell Survival in MMP-2 Null Mice Suggest a Role for MMP-2 as TNF Sheddase

by Lies De Groef, Manuel Salinas-Navarro, Griet Van Imschoot, Claude Libert, Roosmarijn E. Vandenbroucke, Lieve Moons
Published 2015-01-01

TNFR1 inhibition with a Nanobody protects against EAE development in mice

by Sophie Steeland, Sara Van Ryckeghem, Griet Van Imschoot, Riet De Rycke, Wendy Toussaint, Leen Vanhoutte, Christian Vanhove, Filip De Vos, Roosmarijn E. Vandenbroucke, Claude Libert
Published 2017-10-01

Low-grade peripheral inflammation affects brain pathology in the App NL-G-F mouse model of Alzheimer’s disease

by Junhua Xie, Nina Gorlé, Charysse Vandendriessche, Griet Van Imschoot, Elien Van Wonterghem, Caroline Van Cauwenberghe, Eef Parthoens, Evelien Van Hamme, Saskia Lippens, Lien Van Hoecke, Roosmarijn E. Vandenbroucke
Published 2021-10-01

Importance of extracellular vesicle secretion at the blood–cerebrospinal fluid interface in the pathogenesis of Alzheimer’s disease

by Charysse Vandendriessche, Sriram Balusu, Caroline Van Cauwenberghe, Marjana Brkic, Marie Pauwels, Nele Plehiers, Arnout Bruggeman, Pieter Dujardin, Griet Van Imschoot, Elien Van Wonterghem, An Hendrix, Femke Baeke, Riet De Rycke, Kris Gevaert, Roosmarijn E. Vandenbroucke
Published 2021-08-01

Counteracting the effects of TNF receptor‐1 has therapeutic potential in Alzheimer's disease

by Sophie Steeland, Nina Gorlé, Charysse Vandendriessche, Sriram Balusu, Marjana Brkic, Caroline Van Cauwenberghe, Griet Van Imschoot, Elien Van Wonterghem, Riet De Rycke, Anneke Kremer, Saskia Lippens, Edward Stopa, Conrad E Johanson, Claude Libert, Roosmarijn E Vandenbroucke
Published 2018-04-01

A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation

by Sofie Voet, Conor Mc Guire, Nora Hagemeyer, Arne Martens, Anna Schroeder, Peter Wieghofer, Carmen Daems, Ori Staszewski, Lieselotte Vande Walle, Marta Joana Costa Jordao, Mozes Sze, Hanna-Kaisa Vikkula, Delphine Demeestere, Griet Van Imschoot, Charlotte L. Scott, Esther Hoste, Amanda Gonçalves, Martin Guilliams, Saskia Lippens, Claude Libert, Roos E. Vandenbroucke, Ki-Wook Kim, Steffen Jung, Zsuzsanna Callaerts-Vegh, Patrick Callaerts, Joris de Wit, Mohamed Lamkanfi, Marco Prinz, Geert van Loo
Published 2018-05-01