Protoporphyrins enhance oligomerization and enzymatic activity of HtrA1 serine protease.

by Hakryul Jo, Victoria Patterson, Sean Stoessel, Chia-Yi Kuan, Josephine Hoh
Published 2014-01-01

Natural product Celastrol destabilizes tubulin heterodimer and facilitates mitotic cell death triggered by microtubule-targeting anti-cancer drugs.

by Hakryul Jo, Fabien Loison, Hidenori Hattori, Leslie E Silberstein, Hongtao Yu, Hongbo R Luo
Published 2010-04-01

Neural-specific deletion of Htra2 causes cerebellar neurodegeneration and defective processing of mitochondrial OPA1.

by Victoria L Patterson, Alfred J Zullo, Claire Koenig, Sean Stoessel, Hakryul Jo, Xinran Liu, Jinah Han, Murim Choi, Andrew T DeWan, Jean-Leon Thomas, Chia-Yi Kuan, Josephine Hoh
Published 2014-01-01