Thrombomodulin contributes to gamma tocotrienol-mediated lethality protection and hematopoietic cell recovery in irradiated mice.

by Rupak Pathak, Lijian Shao, Sanchita P Ghosh, Daohong Zhou, Marjan Boerma, Hartmut Weiler, Martin Hauer-Jensen
Published 2015-01-01

A thrombomodulin mutation that impairs active protein C generation is detrimental in severe pneumonia-derived gram-negative sepsis (melioidosis).

by Liesbeth M Kager, W Joost Wiersinga, Joris J T H Roelofs, Onno J de Boer, Hartmut Weiler, Cornelis van 't Veer, Tom van der Poll
Published 2014-04-01

A rat model of severe VWD by elimination of the VWF gene using CRISPR/Cas9

by Jessica Garcia, Veronica H. Flood, Sandra L. Haberichter, Scot A. Fahs, Jeremy G. Mattson, Aron M. Geurts, Mark Zogg, Hartmut Weiler, Qizhen Shi, Robert R. Montgomery
Published 2020-01-01

Sex-dependent effects of genetic upregulation of activated protein C on delayed effects of acute radiation exposure in the mouse heart, small intestine, and skin.

by Vijayalakshmi Sridharan, Kristin A Johnson, Reid D Landes, Maohua Cao, Preeti Singh, Gail Wagoner, Abdallah Hayar, Emily D Sprick, Kayla A Eveld, Anusha Bhattacharyya, Kimberly J Krager, Nukhet Aykin-Burns, Hartmut Weiler, Jose A Fernández, John H Griffin, Marjan Boerma
Published 2021-01-01

Sucrose non-fermenting related kinase enzyme is essential for cardiac metabolism

by Stephanie M. Cossette, Adam J. Gastonguay, Xiaoping Bao, Alexandra Lerch-Gaggl, Ling Zhong, Leanne M. Harmann, Christopher Koceja, Robert Q. Miao, Padmanabhan Vakeel, Changzoon Chun, Keguo Li, Jamie Foeckler, Michelle Bordas, Hartmut Weiler, Jennifer Strande, Sean P. Palecek, Ramani Ramchandran
Published 2014-12-01

Genetic and pharmacological modifications of thrombin formation in apolipoprotein e-deficient mice determine atherosclerosis severity and atherothrombosis onset in a neutrophil-dep...

by Julian I Borissoff, Jeroen J T Otten, Sylvia Heeneman, Peter Leenders, René van Oerle, Oliver Soehnlein, Sarah T B G Loubele, Karly Hamulyák, Tilman M Hackeng, Mat J A P Daemen, Jay L Degen, Hartmut Weiler, Charles T Esmon, Joanne van Ryn, Erik A L Biessen, Henri M H Spronk, Hugo ten Cate
Published 2013-01-01