DNA Adducts Formed by Aristolochic Acid Are Unique Biomarkers of Exposure and Explain the Initiation Phase of Upper Urothelial Cancer

by Marie Stiborová, Volker M. Arlt, Heinz H. Schmeiser
Published 2017-10-01

Mechanisms of Enzyme-Catalyzed Reduction of Two Carcinogenic Nitro-Aromatics, 3-Nitrobenzanthrone and Aristolochic Acid I: Experimental and Theoretical Approaches

by Marie Stiborová, Eva Frei, Heinz H. Schmeiser, Volker M. Arlt, Václav Martínek
Published 2014-06-01

The Histone Deacetylase Inhibitor Valproic Acid Exerts a Synergistic Cytotoxicity with the DNA-Damaging Drug Ellipticine in Neuroblastoma Cells

by Tereza Cerna, Jan Hrabeta, Tomas Eckschlager, Eva Frei, Heinz H. Schmeiser, Volker M. Arlt, Marie Stiborová
Published 2018-01-01

Active Site Mutations as a Suitable Tool Contributing to Explain a Mechanism of Aristolochic Acid I Nitroreduction by Cytochromes P450 1A1, 1A2 and 1B1

by Jan Milichovký, František Bárta, Heinz H. Schmeiser, Volker M. Arlt, Eva Frei, Marie Stiborová, Václav Martínek
Published 2016-02-01

A Mechanism of O-Demethylation of Aristolochic Acid I by Cytochromes P450 and Their Contributions to This Reaction in Human and Rat Livers: Experimental and Theoretical Approaches

by Marie Stiborová, František Bárta, Kateřina Levová, Petr Hodek, Heinz H. Schmeiser, Volker M. Arlt, Václav Martínek
Published 2015-11-01