Targeting Toxins toward Tumors

by Henrik Franzyk, Søren Brøgger Christensen
Published 2021-02-01

Advances in Development of Antimicrobial Peptidomimetics as Potential Drugs

by Natalia Molchanova, Paul R. Hansen, Henrik Franzyk
Published 2017-08-01

Preparation of Enzyme-Activated Thapsigargin Prodrugs by Solid-Phase Synthesis

by Tomas Zimmermann, Søren Brøgger Christensen, Henrik Franzyk
Published 2018-06-01

Adaptive evolution of Escherichia coli to an α-peptide/β-peptoid peptidomimetic induces stable resistance.

by Line Hein-Kristensen, Henrik Franzyk, Anne Holch, Lone Gram
Published 2013-01-01

Peptide/β-Peptoid Hybrids with Activity against Vancomycin-Resistant Enterococci: Influence of Hydrophobicity and Structural Features on Antibacterial and Hemolytic Properties

by Martin Vestergaard, Bolette Skive, Ilona Domraceva, Hanne Ingmer, Henrik Franzyk
Published 2021-05-01

Optimizing the Intracellular Delivery of Therapeutic Anti-inflammatory TNF-α siRNA to Activated Macrophages Using Lipidoid-Polymer Hybrid Nanoparticles

by Abhijeet Lokras, Aneesh Thakur, Abishek Wadhwa, Kaushik Thanki, Henrik Franzyk, Camilla Foged
Published 2021-01-01

In vivo Anti-inflammatory Activity of Lipidated Peptidomimetics Pam-(Lys-βNspe)6-NH2 and Lau-(Lys-βNspe)6-NH2 Against PMA-Induced Acute Inflammation

by Bing C. Wu, Sarah L. Skovbakke, Hamid Masoudi, Robert E. W. Hancock, Henrik Franzyk
Published 2020-08-01

Novel Cyclic Lipopeptide Antibiotics: Effects of Acyl Chain Length and Position

by Signe Kaustrup Jensen, Thomas T. Thomsen, Alberto Oddo, Henrik Franzyk, Anders Løbner-Olesen, Paul R. Hansen
Published 2020-08-01

Structure–Function Characteristics and Signaling Properties of Lipidated Peptidomimetic FPR2 Agonists: Peptoid Stereochemistry and Residues in the Vicinity of the Headgroup Affect...

by Andre Holdfeldt, Sarah Line Skovbakke, Michael Gabl, Christina Nielsen, Claes Dahlgren, Henrik Franzyk, Huamei Forsman
Published 2019-03-01

Antimicrobial Activity of α-Peptide/β-Peptoid Lysine-Based Peptidomimetics Against Colistin-Resistant Pseudomonas aeruginosa Isolated From Cystic Fibrosis Patients

by Natalia Molchanova, Hengzhuang Wang, Paul R. Hansen, Niels Høiby, Niels Høiby, Hanne M. Nielsen, Henrik Franzyk
Published 2019-02-01

High-Resolution PTP1B Inhibition Profiling Combined with HPLC-HRMS-SPE-NMR for Identification of PTP1B Inhibitors from Miconia albicans

by Rita de Cássia Lemos Lima, Kenneth T. Kongstad, Lucília Kato, Marcos José das Silva, Henrik Franzyk, Dan Staerk
Published 2018-07-01

Peptide/β-Peptoid Hybrids with Ultrashort PEG-Like Moieties: Effects on Hydrophobicity, Antibacterial Activity and Hemolytic Properties

by Nicki Frederiksen, Stavroula Louka, Chirag Mudaliar, Ilona Domraceva, Agrita Kreicberga, Osvalds Pugovics, Dorota Żabicka, Magdalena Tomczak, Weronika Wygoda, Fredrik Björkling, Henrik Franzyk
Published 2021-06-01

Repurposing Azithromycin and Rifampicin Against Gram-Negative Pathogens by Combination With Peptidomimetics

by Kristin R. Baker, Kristin R. Baker, Bimal Jana, Bimal Jana, Anna Mette Hansen, Hanne Mørck Nielsen, Henrik Franzyk, Luca Guardabassi, Luca Guardabassi
Published 2019-07-01

The agr Inhibitors Solonamide B and Analogues Alter Immune Responses to Staphylococccus aureus but Do Not Exhibit Adverse Effects on Immune Cell Functions.

by Mara Baldry, Betül Kitir, Hanne Frøkiær, Simon B Christensen, Nico Taverne, Marjolein Meijerink, Henrik Franzyk, Christian A Olsen, Jerry M Wells, Hanne Ingmer
Published 2016-01-01

Philanthotoxin-343 attenuates retinal and optic nerve injury, and protects visual function in rats with N-methyl-D-aspartate-induced excitotoxicity.

by Muhammad Fattah Fazel, Izuddin Fahmy Abu, Mohamad Haiqal Nizar Mohamad, Renu Agarwal, Igor Iezhitsa, Nor Salmah Bakar, Norsham Juliana, Ian R Mellor, Henrik Franzyk
Published 2020-01-01

Fluorescent Analogues of Human α-Calcitonin Gene-Related Peptide with Potent Vasodilator Activity

by Jing Zhu, Mahdieh Dagina Pedersen, Laraib Sabbah Ahmed, Bahareh Abdolalizadeh, Anne-Sofie Grell, Jais Oliver Berg, Peter Waaben Thulstrup, Henrik Franzyk, Lars Edvinsson, Anette Sams, Majid Sheykhzade, Paul Robert Hansen
Published 2020-02-01

Immunogenicity Testing of Lipidoids In Vitro and In Silico: Modulating Lipidoid-Mediated TLR4 Activation by Nanoparticle Design

by Anne Marit de Groot, Kaushik Thanki, Monique Gangloff, Emily Falkenberg, Xianghui Zeng, Djai C.J. van Bijnen, Willem van Eden, Henrik Franzyk, Hanne M. Nielsen, Femke Broere, Nick J. Gay, Camilla Foged, Alice J.A.M. Sijts
Published 2018-06-01