Computational Hypothesis: How Intra-Hepatic Functional Heterogeneity May Influence the Cascading Progression of Free Fatty Acid-Induced Non-Alcoholic Fatty Liver Disease (NAFLD)

by Hermann-Georg Holzhütter, Nikolaus Berndt
Published 2021-03-01

Computer simulations suggest a key role of membranous nanodomains in biliary lipid secretion.

by Johannes Eckstein, Nikolaus Berndt, Hermann-Georg Holzhütter
Published 2015-02-01

Kinetic Modeling of the Mitochondrial Energy Metabolism of Neuronal Cells: The Impact of Reduced α-Ketoglutarate Dehydrogenase Activities on ATP Production and Generation of Reacti...

by Nikolaus Berndt, Sascha Bulik, Hermann-Georg Holzhütter
Published 2012-01-01

Corrigendum to “Kinetic Modeling of the Mitochondrial Energy Metabolism of Neuronal Cells: The Impact of Reduced α-Ketoglutarate Dehydrogenase Activities on ATP Production and Gene...

by Nikolaus Berndt, Sascha Bulik, Hermann-Georg Holzhütter
Published 2018-01-01

Quantifying the contribution of the liver to glucose homeostasis: a detailed kinetic model of human hepatic glucose metabolism.

by Matthias König, Sascha Bulik, Hermann-Georg Holzhütter
Published 2012-01-01

Dynamic Metabolic Zonation of the Hepatic Glucose Metabolism Is Accomplished by Sinusoidal Plasma Gradients of Nutrients and Hormones

by Nikolaus Berndt, Nikolaus Berndt, Hermann-Georg Holzhütter
Published 2018-12-01

Metabolic Consequences of TGFb Stimulation in CulturedPrimary Mouse Hepatocytes Screened from Transcript Data with ModeScore 

by Andreas Hoppe, Iryna Ilkavets, Steven Dooley, Hermann-Georg Holzhütter
Published 2012-11-01

Sequential metabolic phases as a means to optimize cellular output in a constant environment.

by Aljoscha Palinkas, Sascha Bulik, Alexander Bockmayr, Hermann-Georg Holzhütter
Published 2015-01-01

A conceptual mathematical model of the dynamic self-organisation of distinct cellular organelles.

by Bernd Binder, Andrean Goede, Nikolaus Berndt, Hermann-Georg Holzhütter
Published 2009-01-01

A multiscale modelling approach to assess the impact of metabolic zonation and microperfusion on the hepatic carbohydrate metabolism.

by Nikolaus Berndt, Marius Stefan Horger, Sascha Bulik, Hermann-Georg Holzhütter
Published 2018-02-01

Computational lipidology: predicting lipoprotein density profiles in human blood plasma.

by Katrin Hübner, Thomas Schwager, Karl Winkler, Jens-Georg Reich, Hermann-Georg Holzhütter
Published 2008-05-01

Assessment of hepatic detoxification activity: proposal of an improved variant of the (13)c-methacetin breath test.

by Hermann-Georg Holzhütter, Johan Friso Lock, Pouria Taheri, Sascha Bulik, Andrean Goede, Martin Stockmann
Published 2013-01-01

Quantitative time-resolved analysis reveals intricate, differential regulation of standard- and immuno-proteasomes

by Juliane Liepe, Hermann-Georg Holzhütter, Elena Bellavista, Peter M Kloetzel, Michael PH Stumpf, Michele Mishto
Published 2015-09-01

Evaluation of 41 candidate gene variants for obesity in the EPIC-Potsdam cohort by multi-locus stepwise regression.

by Sven Knüppel, Klaus Rohde, Karina Meidtner, Dagmar Drogan, Hermann-Georg Holzhütter, Heiner Boeing, Eva Fisher
Published 2013-01-01

Characterization of Lipid and Lipid Droplet Metabolism in Human HCC

by Nikolaus Berndt, Johannes Eckstein, Niklas Heucke, Robert Gajowski, Martin Stockmann, David Meierhofer, Hermann-Georg Holzhütter
Published 2019-05-01

HEPATOKIN1 is a biochemistry-based model of liver metabolism for applications in medicine and pharmacology

by Nikolaus Berndt, Sascha Bulik, Iwona Wallach, Tilo Wünsch, Matthias König, Martin Stockmann, David Meierhofer, Hermann-Georg Holzhütter
Published 2018-06-01

In vitro proteasome processing of neo-splicetopes does not predict their presentation in vivo

by Gerald Willimsky, Christin Beier, Lena Immisch, George Papafotiou, Vivian Scheuplein, Andrean Goede, Hermann-Georg Holzhütter, Thomas Blankenstein, Peter M Kloetzel
Published 2021-04-01

Changes in Liver Mechanical Properties and Water Diffusivity During Normal Pregnancy Are Driven by Cellular Hypertrophy

by Karolina Garczyńska, Heiko Tzschätzsch, Anja A. Kühl, Anna Sophie Morr, Ledia Lilaj, Akvile Häckel, Eyk Schellenberger, Nikolaus Berndt, Nikolaus Berndt, Hermann-Georg Holzhütter, Jürgen Braun, Ingolf Sack, Jing Guo
Published 2020-11-01

Effect of Post-mortem Interval and Perfusion on the Biophysical Properties of ex vivo Liver Tissue Investigated Longitudinally by MRE and DWI

by Karolina Garczyńska, Karolina Garczyńska, Heiko Tzschätzsch, Sanam Assili, Sanam Assili, Anja A. Kühl, Akvile Häckel, Eyk Schellenberger, Nikolaus Berndt, Nikolaus Berndt, Hermann-Georg Holzhütter, Jürgen Braun, Ingolf Sack, Jing Guo
Published 2021-08-01

The Axonal Membrane Protein PRG2 Inhibits PTEN and Directs Growth to Branches

by Annika Brosig, Joachim Fuchs, Fatih Ipek, Cristina Kroon, Sandra Schrötter, Mayur Vadhvani, Alexandra Polyzou, Julia Ledderose, Michiel van Diepen, Hermann-Georg Holzhütter, Thorsten Trimbuch, Niclas Gimber, Jan Schmoranzer, Ivo Lieberam, Christian Rosenmund, Christian Spahn, Patrick Scheerer, Michal Szczepek, George Leondaritis, Britta J. Eickholt
Published 2019-11-01