On the potential alternate binding change mechanism in a dimeric structure of Pyruvate Phosphate Dikinase

by Daniel Ciupka, Holger Gohlke
Published 2017-08-01

Ligand-mediated and tertiary interactions cooperatively stabilize the P1 region in the guanine-sensing riboswitch.

by Christian A Hanke, Holger Gohlke
Published 2017-01-01

Structural Rigidity and Protein Thermostability in Variants of Lipase A from Bacillus subtilis.

by Prakash Chandra Rathi, Karl-Erich Jaeger, Holger Gohlke
Published 2015-01-01

DrugScorePPI knowledge-based potentials used as scoring and objective function in protein-protein docking.

by Dennis M Krüger, José Ignacio Garzón, Pablo Chacón, Holger Gohlke
Published 2014-01-01

Discovery of new acetylcholinesterase inhibitors for Alzheimer’s disease: virtual screening and in vitro characterisation

by Benoit David, Pascal Schneider, Philipp Schäfer, Jörg Pietruszka, Holger Gohlke
Published 2021-01-01

Application of Rigidity Theory to the Thermostabilization of Lipase A from Bacillus subtilis.

by Prakash Chandra Rathi, Alexander Fulton, Karl-Erich Jaeger, Holger Gohlke
Published 2016-03-01

The Puzzle of Metabolite Exchange and Identification of Putative Octotrico Peptide Repeat Expression Regulators in the Nascent Photosynthetic Organelles of Paulinella chromatophora

by Linda Oberleitner, Gereon Poschmann, Luis Macorano, Stephan Schott-Verdugo, Stephan Schott-Verdugo, Holger Gohlke, Holger Gohlke, Kai Stühler, Kai Stühler, Eva C. M. Nowack
Published 2020-11-01

40 Years of Research on Polybrominated Diphenyl Ethers (PBDEs)—A Historical Overview and Newest Data of a Promising Anticancer Drug

by Laura Schmitt, Ilka Hinxlage, Pablo A. Cea, Holger Gohlke, Sebastian Wesselborg
Published 2021-02-01

Novel 3,4-Dihydroisocoumarins Inhibit Human P-gp and BCRP in Multidrug Resistant Tumors and Demonstrate Substrate Inhibition of Yeast Pdr5

by Julia Sachs, Katja Döhl, Anja Weber, Michele Bonus, Ferdinand Ehlers, Edmond Fleischer, Anette Klinger, Holger Gohlke, Holger Gohlke, Jörg Pietruszka, Jörg Pietruszka, Lutz Schmitt, Nicole Teusch
Published 2019-04-01

Foamy Viruses, Bet, and APOBEC3 Restriction

by Ananda Ayyappan Jaguva Vasudevan, Daniel Becker, Tom Luedde, Holger Gohlke, Carsten Münk
Published 2021-03-01

Molecular Mechanisms of Glutamine Synthetase Mutations that Lead to Clinically Relevant Pathologies.

by Benedikt Frieg, Boris Görg, Nadine Homeyer, Verena Keitel, Dieter Häussinger, Holger Gohlke
Published 2016-02-01

Structure of the Response Regulator NsrR from Streptococcus agalactiae, Which Is Involved in Lantibiotic Resistance.

by Sakshi Khosa, Astrid Hoeppner, Holger Gohlke, Lutz Schmitt, Sander H J Smits
Published 2016-01-01

Can constraint network analysis guide the identification phase of KnowVolution? A case study on improved thermostability of an endo-β-glucanase

by Francisca Contreras, Christina Nutschel, Laura Beust, Mehdi D. Davari, Holger Gohlke, Ulrich Schwaneberg
Published 2021-01-01

Redesigning Aldolase Stereoselectivity by Homologous Grafting.

by Carolin Bisterfeld, Thomas Classen, Irene Küberl, Birgit Henßen, Alexander Metz, Holger Gohlke, Jörg Pietruszka
Published 2016-01-01

Aqueous ionic liquids redistribute local enzyme stability via long-range perturbation pathways

by Till El Harrar, Benedikt Frieg, Mehdi D. Davari, Karl-Erich Jaeger, Ulrich Schwaneberg, Holger Gohlke
Published 2021-01-01

Quantitative assessment of the determinant structural differences between redox-active and inactive glutaredoxins

by Linda Liedgens, Jannik Zimmermann, Lucas Wäschenbach, Fabian Geissel, Hugo Laporte, Holger Gohlke, Bruce Morgan, Marcel Deponte
Published 2020-04-01

Resolving hot spots in the C-terminal dimerization domain that determine the stability of the molecular chaperone Hsp90.

by Emanuele Ciglia, Janina Vergin, Sven Reimann, Sander H J Smits, Lutz Schmitt, Georg Groth, Holger Gohlke
Published 2014-01-01

A Novel Polyester Hydrolase From the Marine Bacterium Pseudomonas aestusnigri – Structural and Functional Insights

by Alexander Bollinger, Stephan Thies, Esther Knieps-Grünhagen, Christoph Gertzen, Christoph Gertzen, Stefanie Kobus, Astrid Höppner, Manuel Ferrer, Holger Gohlke, Holger Gohlke, Sander H. J. Smits, Sander H. J. Smits, Karl-Erich Jaeger, Karl-Erich Jaeger
Published 2020-02-01

Contribution of single amino acid and codon substitutions to the production and secretion of a lipase by Bacillus subtilis

by Pia Skoczinski, Kristina Volkenborn, Alexander Fulton, Anuseema Bhadauriya, Christina Nutschel, Holger Gohlke, Andreas Knapp, Karl-Erich Jaeger
Published 2017-09-01

Automated and optimally FRET-assisted structural modeling

by Mykola Dimura, Thomas-Otavio Peulen, Hugo Sanabria, Dmitro Rodnin, Katherina Hemmen, Christian A. Hanke, Claus A. M. Seidel, Holger Gohlke
Published 2020-10-01