The Effects of Repeat-Dose Doxorubicin on Cardiovascular Functional Endpoints and Biomarkers in the Telemetry-Equipped Cynomolgus Monkey

by Michael J. Engwall, Nancy Everds, James R. Turk, Hugo M. Vargas
Published 2021-02-01

Comprehensive in vitro pro‐arrhythmic assays demonstrate that omecamtiv mecarbil has low pro‐arrhythmic risk

by Yusheng Qu, BaoXi Gao, Ziva Arimura, Mei Fang, Hugo M. Vargas
Published 2021-07-01

Action Potential Recording and Pro-arrhythmia Risk Analysis in Human Ventricular Trabeculae

by Yusheng Qu, Guy Page, Najah Abi-Gerges, Paul E. Miller, Andre Ghetti, Hugo M. Vargas
Published 2018-01-01

Blinded In Silico Drug Trial Reveals the Minimum Set of Ion Channels for Torsades de Pointes Risk Assessment

by Xin Zhou, Yusheng Qu, Elisa Passini, Alfonso Bueno-Orovio, Yang Liu, Hugo M. Vargas, Blanca Rodriguez
Published 2020-01-01

Clinical Implications and Translation of an Off-Target Pharmacology Profiling Hit: Adenosine Uptake Inhibition In Vitro

by Hamid R. Amouzadeh, Isaiah Dimery, Jonathan Werner, Gataree Ngarmchamnanrith, Michael J Engwall, Hugo M. Vargas, Deborah Arrindell
Published 2019-10-01