What is an estimand & how does it relate to quantifying the effect of treatment on patient-reported quality of life outcomes in clinical trials?

by Rachael Lawrance, Evgeny Degtyarev, Philip Griffiths, Peter Trask, Helen Lau, Denise D’Alessio, Ingolf Griebsch, Gudrun Wallenstein, Kim Cocks, Kaspar Rufibach
Published 2020-08-01

SPIRIT-PRO Extension explanation and elaboration: guidelines for inclusion of patient-reported outcomes in protocols of clinical trials

by Kirstie Haywood, Ameeta Retzer, Anita Slade, Melanie Calvert, Jane Blazeby, Rebecca Mercieca-Bebber, Antonia Bennett, Carolyn Ells, Gary Price, Galina Velikova, Heather Draper, Dennis Revicki, Julia Brown, Lori Frank, Madeleine King, Jane Scott, Sandra Mitchell, Grace Turner, Michael Brundage, Andrew Bottomley, Michael Palmer, Richard Stephens, Ingolf Griebsch, Donald Patrick, Lari Wenzel, Daniel O'Connor, Robert M Golub, Olalekan Aiyegbusi, E Basch, Jill Bell, Vishal Bhatnagar, Lisa Campbell, Amylou C Dueck, Amanda Hunn, Bellinda King-Kallimanis, Thomas Morel, Linda Nelson, Josephine Norquist, Antoine Regnault, Antonia Valakas, Maria von Hildebrand, Anita Walker
Published 2021-06-01