Insulin resistance induced by hyperinsulinemia coincides with a persistent alteration at the insulin receptor tyrosine kinase domain.

by Karyn J Catalano, Betty A Maddux, Jaroslaw Szary, Jack F Youngren, Ira D Goldfine, Fred Schaufele
Published 2014-01-01

Role of gut microbiota and oxidative stress in the progression of non-alcoholic fatty liver disease to hepatocarcinoma: Current and innovative therapeutic approaches

by Antonella Borrelli, Patrizia Bonelli, Franca Maria Tuccillo, Ira D. Goldfine, Joseph L. Evans, Franco Maria Buonaguro, Aldo Mancini
Published 2018-05-01

Insulin resistance in non-obese subjects is associated with activation of the JNK pathway and impaired insulin signaling in skeletal muscle.

by Umesh B Masharani, Betty A Maddux, Xiaojuan Li, Giorgos K Sakkas, Kathleen Mulligan, Morris Schambelan, Ira D Goldfine, Jack F Youngren
Published 2011-05-01

Improved glucose metabolism in vitro and in vivo by an allosteric monoclonal antibody that increases insulin receptor binding affinity.

by John A Corbin, Vinay Bhaskar, Ira D Goldfine, Daniel H Bedinger, Angela Lau, Kristen Michelson, Lisa M Gross, Betty A Maddux, Hua F Kuan, Catarina Tran, Llewelyn Lao, Masahisa Handa, Susan R Watson, Ajay J Narasimha, Shirley Zhu, Raphael Levy, Lynn Webster, Sujeewa D Wijesuriya, Naichi Liu, Xiaorong Wu, David Chemla-Vogel, Steve R Lee, Steve Wong, Diane Wilcock, Mark L White
Published 2014-01-01