Immunogenicity of Immunotoxins Containing Pseudomonas Exotoxin A: Causes, Consequences, and Mitigation

by Ronit Mazor, Ira Pastan
Published 2020-06-01

Mechanisms of Resistance to Immunotoxins Containing <i>Pseudomonas</i> Exotoxin A in Cancer Therapy

by Michael Dieffenbach, Ira Pastan
Published 2020-06-01

Pseudomonas Exotoxin Immunotoxins and Anti-Tumor Immunity: From Observations at the Patient’s Bedside to Evaluation in Preclinical Models

by Yasmin Leshem, Ira Pastan
Published 2019-01-01

Development of Recombinant Immunotoxins for Hairy Cell Leukemia

by Robert J. Kreitman, Ira Pastan
Published 2020-08-01

Immunotoxin complementation of HAART to deplete persisting HIV-infected cell reservoirs.

by Edward A Berger, Ira Pastan
Published 2010-06-01

Combination treatments with the PKC inhibitor, enzastaurin, enhance the cytotoxicity of the anti-mesothelin immunotoxin, SS1P.

by Abid R Mattoo, Ira Pastan, David Fitzgerald
Published 2013-01-01

Effect of antigen shedding on targeted delivery of immunotoxins in solid tumors from a mathematical model.

by Youngshang Pak, Ira Pastan, Robert J Kreitman, Byungkook Lee
Published 2014-01-01

Methylation-associated partial down-regulation of mesothelin causes resistance to anti-mesothelin immunotoxins in a pancreatic cancer cell line.

by Kevin Hollevoet, Emily Mason-Osann, Fabian Müller, Ira Pastan
Published 2015-01-01

Toxin-Based Targeted Therapy for Malignant Brain Tumors

by Vidyalakshmi Chandramohan, John H. Sampson, Ira Pastan, Darell D. Bigner
Published 2012-01-01

SS1P Immunotoxin Induces Markers of Immunogenic Cell Death and Enhances the Effect of the CTLA-4 Blockade in AE17M Mouse Mesothelioma Tumors

by Yasmin Leshem, Emily M. King, Ronit Mazor, Yoram Reiter, Ira Pastan
Published 2018-11-01

Domain II of Pseudomonas Exotoxin Is Critical for Efficacy of Bolus Doses in a Xenograft Model of Acute Lymphoblastic Leukemia

by Fabian Müller, Tyler Cunningham, Richard Beers, Tapan K. Bera, Alan S. Wayne, Ira Pastan
Published 2018-05-01

Anti-TGF-β Antibody, 1D11, Ameliorates Glomerular Fibrosis in Mouse Models after the Onset of Proteinuria.

by Xiaoyan Liang, H William Schnaper, Taiji Matsusaka, Ira Pastan, Steve Ledbetter, Tomoko Hayashida
Published 2016-01-01

Diphthamide affects selenoprotein expression: Diphthamide deficiency reduces selenocysteine incorporation, decreases selenite sensitivity and pre-disposes to oxidative stress

by Klaus Mayer, Olaf Mundigl, Hubert Kettenberger, Fabian Birzele, Sebastian Stahl, Ira Pastan, Ulrich Brinkmann
Published 2019-01-01

Protection of the Furin Cleavage Site in Low-Toxicity Immunotoxins Based on Pseudomonas Exotoxin A

by Gilad Kaplan, Fred Lee, Masanori Onda, Emily Kolyvas, Gaurav Bhardwaj, David Baker, Ira Pastan
Published 2016-07-01

Efficiency of immunotoxin cytotoxicity is modulated by the intracellular itinerary.

by Lori L Tortorella, Nina H Pipalia, Sushmita Mukherjee, Ira Pastan, David Fitzgerald, Frederick R Maxfield
Published 2012-01-01

Megakaryocytic potentiating factor and mature mesothelin stimulate the growth of a lung cancer cell line in the peritoneal cavity of mice.

by Jingli Zhang, Tapan K Bera, Wenhai Liu, Xing Du, Christine Alewine, Raffit Hassan, Ira Pastan
Published 2014-01-01

ANKRD26 and its interacting partners TRIO, GPS2, HMMR and DIPA regulate adipogenesis in 3T3-L1 cells.

by Xiu-Fen Liu, Tapan K Bera, Charissa Kahue, Thelma Escobar, Zhaoliang Fei, Gregory A Raciti, Ira Pastan
Published 2012-01-01

Identification and enhancement of HLA-A2.1-restricted CTL epitopes in a new human cancer antigen-POTE.

by Yi-Hsiang Huang, Masaki Terabe, C David Pendleton, Deborah Stewart Khursigara, Tapan K Bera, Ira Pastan, Jay A Berzofsky
Published 2013-01-01

Imaging of Convection Enhanced Delivery of Toxins in Humans

by Allan H. Friedman, Darell D. Bigner, John H. Sampson, Ira Pastan, Martin Brady, Raghu Raghavan, Bryan D. Choi, Ankit I. Mehta
Published 2011-03-01

5’UTR point substitutions and N-terminal truncating mutations of ANKRD26 in acute myeloid leukemia

by Caterina Marconi, Ilaria Canobbio, Valeria Bozzi, Tommaso Pippucci, Giorgia Simonetti, Federica Melazzini, Silvia Angori, Giovanni Martinelli, Giuseppe Saglio, Mauro Torti, Ira Pastan, Marco Seri, Alessandro Pecci
Published 2017-01-01