Steered molecular dynamics simulations reveal critical residues for (un)binding of substrates, inhibitors and a product to the malarial M1 aminopeptidase.

by Daniel S Moore, Conor Brines, Heather Jewhurst, John P Dalton, Irina G Tikhonova
Published 2018-10-01

Fasciola hepatica serine protease inhibitor family (serpins): Purposely crafted for regulating host proteases.

by Carolina De Marco Verissimo, Heather L Jewhurst, Irina G Tikhonova, Rolf T Urbanus, Aaron G Maule, John P Dalton, Krystyna Cwiklinski
Published 2020-08-01

Structural basis of the membrane intramolecular transacylase reaction responsible for lyso-form lipoprotein synthesis

by Samir Olatunji, Katherine Bowen, Chia-Ying Huang, Dietmar Weichert, Warispreet Singh, Irina G. Tikhonova, Eoin M. Scanlan, Vincent Olieric, Martin Caffrey
Published 2021-07-01

Regulation of the Fasciola hepatica newly excysted juvenile cathepsin L3 (FhCL3) by its propeptide: a proposed ‘clamp-like’ mechanism of binding and inhibition

by Izanara C. Pritsch, Irina G. Tikhonova, Heather L. Jewhurst, Orla Drysdale, Krystyna Cwiklinski, Marcelo B. Molento, John P. Dalton, Carolina De M. Verissimo
Published 2020-12-01