Changes in nano-mechanical properties of human epidermal cornified cells in children with atopic dermatitis [version 2; peer review: 2 approved]

by Marek Haftek, Maeve A McAleer, Ivone Jakasa, WH Irwin McLean, Sanja Kezic, Alan D. Irvine
Published 2020-07-01

A lack of premature termination codon read-through efficacy of PTC124 (Ataluren) in a diverse array of reporter assays.

by Stuart P McElroy, Toshifumi Nomura, Leah S Torrie, Emma Warbrick, Ulrike Gartner, Gavin Wood, W H Irwin McLean
Published 2013-01-01

Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis

by Jonathan Martínez-Fábregas, Alan Prescott, Sander van Kasteren, Deena Leslie Pedrioli, Irwin McLean, Anna Moles, Thomas Reinheckel, Valeria Poli, Colin Watts
Published 2018-12-01

Carrier status for the common R501X and 2282del4 filaggrin mutations is not associated with hearing phenotypes in 5,377 children from the ALSPAC cohort.

by Santiago Rodriguez, Amanda J Hall, Raquel Granell, W H Irwin McLean, Alan D Irvine, Colin N A Palmer, George Davey Smith, John Henderson, Ian N M Day
Published 2009-06-01

Improved annotation of 3' untranslated regions and complex loci by combination of strand-specific direct RNA sequencing, RNA-Seq and ESTs.

by Nicholas J Schurch, Christian Cole, Alexander Sherstnev, Junfang Song, Céline Duc, Kate G Storey, W H Irwin McLean, Sara J Brown, Gordon G Simpson, Geoffrey J Barton
Published 2014-01-01

Gene-environment interaction in the onset of eczema in infancy: filaggrin loss-of-function mutations enhanced by neonatal cat exposure.

by Hans Bisgaard, Angela Simpson, Colin N A Palmer, Klaus Bønnelykke, Irwin McLean, Somnath Mukhopadhyay, Christian B Pipper, Liselotte B Halkjaer, Brian Lipworth, Jenny Hankinson, Ashley Woodcock, Adnan Custovic
Published 2008-06-01

Generation and characterisation of keratin 7 (K7) knockout mice.

by Aileen Sandilands, Frances J D Smith, Declan P Lunny, Linda E Campbell, Kirsty M Davidson, Stephanie F MacCallum, Laura D Corden, Lesley Christie, Stewart Fleming, E Birgitte Lane, W H Irwin McLean
Published 2013-01-01

Development of allele-specific therapeutic siRNA in Meesmann epithelial corneal dystrophy.

by Haihui Liao, Alan D Irvine, Caroline J Macewen, Kathryn H Weed, Louise Porter, Laura D Corden, A Bethany Gibson, Jonathan E Moore, Frances J D Smith, W H Irwin McLean, C B Tara Moore
Published 2011-01-01

Lysyl Hydroxylase 3 Localizes to Epidermal Basement Membrane and Is Reduced in Patients with Recessive Dystrophic Epidermolysis Bullosa.

by Stephen A Watt, Jasbani H S Dayal, Sheila Wright, Megan Riddle, Celine Pourreyron, James R McMillan, Roy M Kimble, Marco Prisco, Ulrike Gartner, Emma Warbrick, W H Irwin McLean, Irene M Leigh, John A McGrath, Julio C Salas-Alanis, Jakub Tolar, Andrew P South
Published 2015-01-01