A novel angiotensin I-converting enzyme mutation (S333W) impairs N-domain enzymatic cleavage of the anti-fibrotic peptide, AcSDKP.

by Sergei M Danilov, Michael S Wade, Sylva L Schwager, Ross G Douglas, Andrew B Nesterovitch, Isolda A Popova, Kyle D Hogarth, Nakul Bhardwaj, David E Schwartz, Edward D Sturrock, Joe G N Garcia
Published 2014-01-01

An angiotensin I-converting enzyme mutation (Y465D) causes a dramatic increase in blood ACE via accelerated ACE shedding.

by Sergei M Danilov, Kerry Gordon, Andrew B Nesterovitch, Heinrich Lünsdorf, Zhenlong Chen, Maricela Castellon, Isolda A Popova, Sergey Kalinin, Emma Mendonca, Pavel A Petukhov, David E Schwartz, Richard D Minshall, Edward D Sturrock
Published 2011-01-01

A novel splice-site mutation in angiotensin I-converting enzyme (ACE) gene, c.3691+1G>A (IVS25+1G>A), causes a dramatic increase in circulating ACE through deletion of the transmem...

by Alexandre Persu, Michel Lambert, Jaap Deinum, Marta Cossu, Nathalie de Visscher, Leonid Irenge, Jerôme Ambroise, Jean-Marc Minon, Andrew B Nesterovitch, Alexander Churbanov, Isolda A Popova, Sergei M Danilov, A H Jan Danser, Jean-Luc Gala
Published 2013-01-01