Linking hnRNP Function to ALS and FTD Pathology

by Maria D. Purice, J. Paul Taylor, J. Paul Taylor
Published 2018-05-01

Huntingtin fragments and SOD1 mutants form soluble oligomers in the cell.

by Yang-Nim Park, Xiaohong Zhao, Mark Norton, J Paul Taylor, Evan Eisenberg, Lois E Greene
Published 2012-01-01

Chronic optogenetic induction of stress granules is cytotoxic and reveals the evolution of ALS-FTD pathology

by Peipei Zhang, Baochang Fan, Peiguo Yang, Jamshid Temirov, James Messing, Hong Joo Kim, J Paul Taylor
Published 2019-03-01

Network analyses reveal novel aspects of ALS pathogenesis.

by Mario Sanhueza, Andrea Chai, Colin Smith, Brett A McCray, T Ian Simpson, J Paul Taylor, Giuseppa Pennetta
Published 2015-03-01

A novel conserved isoform of the ubiquitin ligase UFD2a/UBE4B is expressed exclusively in mature striated muscle cells.

by Andrew L Mammen, James A Mahoney, Amanda St Germain, Nisha Badders, J Paul Taylor, Antony Rosen, Sarah Spinette
Published 2011-01-01

hnRNPDL Phase Separation Is Regulated by Alternative Splicing and Disease-Causing Mutations Accelerate Its Aggregation

by Cristina Batlle, Peiguo Yang, Maura Coughlin, James Messing, Mireia Pesarrodona, Elzbieta Szulc, Xavier Salvatella, Hong Joo Kim, J. Paul Taylor, Salvador Ventura
Published 2020-01-01

Histone deacetylases suppress CGG repeat-induced neurodegeneration via transcriptional silencing in models of fragile X tremor ataxia syndrome.

by Peter K Todd, Seok Yoon Oh, Amy Krans, Udai B Pandey, Nicholas A Di Prospero, Kyung-Tai Min, J Paul Taylor, Henry L Paulson
Published 2010-12-01

TDP-43 and PINK1 mediate CHCHD10 S59L mutation–induced defects in Drosophila and in vitro

by Minwoo Baek, Yun-Jeong Choe, Sylvie Bannwarth, JiHye Kim, Swati Maitra, Gerald W. Dorn, J. Paul Taylor, Veronique Paquis-Flucklinger, Nam Chul Kim
Published 2021-03-01

Author Correction: TDP-43 and PINK1 mediate CHCHD10 S59L mutation–induced defects in Drosophila and in vitro

by Minwoo Baek, Yun-Jeong Choe, Sylvie Bannwarth, JiHye Kim, Swati Maitra, Gerald W. Dorn, J. Paul Taylor, Veronique Paquis-Flucklinger, Nam Chul Kim
Published 2021-05-01

Clinical and neuropathological features of ALS/FTD with TIA1 mutations

by Veronica Hirsch-Reinshagen, Cyril Pottier, Alexandra M. Nicholson, Matt Baker, Ging-Yuek R. Hsiung, Charles Krieger, Pheth Sengdy, Kevin B. Boylan, Dennis W. Dickson, Marsel Mesulam, Sandra Weintraub, Eileen Bigio, Lorne Zinman, Julia Keith, Ekaterina Rogaeva, Sasha A. Zivkovic, David Lacomis, J. Paul Taylor, Rosa Rademakers, Ian R. A. Mackenzie
Published 2017-12-01

Machine learning suggests polygenic risk for cognitive dysfunction in amyotrophic lateral sclerosis

by Katerina Placek, Michael Benatar, Joanne Wuu, Evadnie Rampersaud, Laura Hennessy, Vivianna M Van Deerlin, Murray Grossman, David J Irwin, Lauren Elman, Leo McCluskey, Colin Quinn, Volkan Granit, Jeffrey M Statland, Ted M Burns, John Ravits, Andrea Swenson, Jon Katz, Erik P Pioro, Carlayne Jackson, James Caress, Yuen So, Samuel Maiser, David Walk, Edward B Lee, John Q Trojanowski, Philip Cook, James Gee, Jin Sha, Adam C Naj, Rosa Rademakers, The CReATe Consortium, Wenan Chen, Gang Wu, J Paul Taylor, Corey T McMillan
Published 2021-01-01