Clustered DNA Double-Strand Breaks: Biological Effects and Relevance to Cancer Radiotherapy

by Jac A. Nickoloff, Neelam Sharma, Lynn Taylor
Published 2020-01-01

The Safe Path at the Fork: Ensuring Replication-Associated DNA Double-Strand Breaks are Repaired by Homologous Recombination

by Jac A. Nickoloff, Neelam Sharma, Lynn Taylor, Sage J. Allen, Robert Hromas
Published 2021-09-01

Metnase mediates resistance to topoisomerase II inhibitors in breast cancer cells.

by Justin Wray, Elizabeth A Williamson, Melanie Royce, Montaser Shaheen, Brian D Beck, Suk-Hee Lee, Jac A Nickoloff, Robert Hromas
Published 2009-01-01

The endonuclease EEPD1 mediates synthetic lethality in RAD52-depleted BRCA1 mutant breast cancer cells

by Robert Hromas, Hyun-Suk Kim, Gurjit Sidhu, Elizabeth Williamson, Aruna Jaiswal, Taylor A. Totterdale, Jocelyn Nole, Suk-Hee Lee, Jac A. Nickoloff, Kimi Y. Kong
Published 2017-11-01

Neoamphimedine Circumvents Metnase-Enhanced DNA Topoisomerase IIα Activity Through ATP-Competitive Inhibition

by Philip Reigan, Brian G. Reid, Qiong Zhou, Amanda K. Ashley, Jac A. Nickoloff, Robert Hromas, Daniel V. LaBarbera, Courtney L. Amerin, Qun Li, Adedoyin D. Abraham, Byong Hoon Yoo, Jessica Ponder
Published 2011-11-01

DNA damage response proteins and oxygen modulate prostaglandin E2 growth factor release in response to low and high LET ionizing radiation

by Christopher P. Allen, Walter eTinganelli, Neelam eSharma, Jingyi eNie, Cory eSicard, Francesco eNatale, Maurice eKing, Stephen B. Keysar, Antonio eJimeno, Yoshiya eFurasawa, Ryuichi eOkayasu, Akira eFujimori, Marco eDurante, Jac A Nickoloff
Published 2015-12-01

EEPD1 Rescues Stressed Replication Forks and Maintains Genome Stability by Promoting End Resection and Homologous Recombination Repair.

by Yuehan Wu, Suk-Hee Lee, Elizabeth A Williamson, Brian L Reinert, Ju Hwan Cho, Fen Xia, Aruna Shanker Jaiswal, Gayathri Srinivasan, Bhavita Patel, Alexis Brantley, Daohong Zhou, Lijian Shao, Rupak Pathak, Martin Hauer-Jensen, Sudha Singh, Kimi Kong, Xaiohua Wu, Hyun-Suk Kim, Timothy Beissbarth, Jochen Gaedcke, Sandeep Burma, Jac A Nickoloff, Robert A Hromas
Published 2015-12-01