Construction and optimization of gene expression signatures for prediction of survival in two-arm clinical trials

by Joachim Theilhaber, Marielle Chiron, Jennifer Dreymann, Donald Bergstrom, Jack Pollard
Published 2020-07-01

Gene expression profiling of a hypoxic seizure model of epilepsy suggests a role for mTOR and Wnt signaling in epileptogenesis.

by Joachim Theilhaber, Sanjay N Rakhade, Judy Sudhalter, Nayantara Kothari, Peter Klein, Jack Pollard, Frances E Jensen
Published 2013-01-01

Glutaminase is essential for the growth of triple-negative breast cancer cells with a deregulated glutamine metabolism pathway and its suppression synergizes with mTOR inhibition.

by Michael Lampa, Heike Arlt, Timothy He, Beatriz Ospina, Jason Reeves, Bailin Zhang, Joshua Murtie, Gejing Deng, Claude Barberis, Dietmar Hoffmann, Hong Cheng, Jack Pollard, Christopher Winter, Victoria Richon, Carlos Garcia-Escheverria, Francisco Adrian, Dmitri Wiederschain, Lakshmi Srinivasan
Published 2017-01-01

Pan-TGFβ inhibition by SAR439459 relieves immunosuppression and improves antitumor efficacy of PD-1 blockade

by Rita Greco, Hongjing Qu, Hui Qu, Joachim Theilhaber, Gary Shapiro, Richard Gregory, Christopher Winter, Natalia Malkova, Frank Sun, Julie Jaworski, Annie Best, Lily Pao, Andrew Hebert, Mikhail Levit, Alexei Protopopov, Jack Pollard, Keith Bahjat, Dmitri Wiederschain, Sharad Sharma
Published 2020-01-01

An experimental model of anti-PD-1 resistance exhibits activation of TGFß and Notch pathways and is sensitive to local mRNA immunotherapy

by Marie Bernardo, Tatiana Tolstykh, Yu-an Zhang, Dinesh S. Bangari, Hui Cao, Kerstin A. Heyl, Joon Sang Lee, Natalia V. Malkova, Katie Malley, Eladio Marquez, Jack Pollard, Hui Qu, Errin Roberts, Sue Ryan, Kuldeep Singh, Fangxian Sun, Emma Wang, Keith Bahjat, Dmitri Wiederschain, Timothy R. Wagenaar
Published 2021-01-01

Demonstrating trustworthiness when collecting and sharing genomic data: public views across 22 countries

by Richard Milne, Katherine I. Morley, Mohamed A. Almarri, Shamim Anwer, Jerome Atutornu, Elena E. Baranova, Paul Bevan, Maria Cerezo, Yali Cong, Alessia Costa, Christine Critchley, Josepine Fernow, Peter Goodhand, Qurratulain Hasan, Aiko Hibino, Gry Houeland, Heidi C. Howard, S. Zakir Hussain, Charlotta Ingvoldstad Malmgren, Vera L. Izhevskaya, Aleksandra Jędrzejak, Cao Jinhong, Megumi Kimura, Erika Kleiderman, Brandi Leach, Keying Liu, Deborah Mascalzoni, Álvaro Mendes, Jusaku Minari, Dianne Nicol, Emilia Niemiec, Christine Patch, Jack Pollard, Barbara Prainsack, Marie Rivière, Lauren Robarts, Jonathan Roberts, Virginia Romano, Haytham A. Sheerah, James Smith, Alexandra Soulier, Claire Steed, Vigdis Stefànsdóttir, Cornelia Tandre, Adrian Thorogood, Torsten H. Voigt, Nan Wang, Anne V. West, Go Yoshizawa, Anna Middleton
Published 2021-05-01