Reversible resistance induced by FLT3 inhibition: a novel resistance mechanism in mutant FLT3-expressing cells.

by Ellen Weisberg, Arghya Ray, Erik Nelson, Sophia Adamia, Rosemary Barrett, Martin Sattler, Chengsheng Zhang, John F Daley, David Frank, Edward Fox, James D Griffin
Published 2011-01-01

Selective Akt inhibitors synergize with tyrosine kinase inhibitors and effectively override stroma-associated cytoprotection of mutant FLT3-positive AML cells.

by Ellen Weisberg, Qingsong Liu, Xin Zhang, Erik Nelson, Martin Sattler, Feiyang Liu, Maria Nicolais, Jianming Zhang, Constantine Mitsiades, Robert W Smith, Richard Stone, Ilene Galinsky, Atsushi Nonami, James D Griffin, Nathanael Gray
Published 2013-01-01

The CRTC1-MAML2 fusion is the major oncogenic driver in mucoepidermoid carcinoma

by Zirong Chen, Wei Ni, Jian-Liang Li, Shuibin Lin, Xin Zhou, Yuping Sun, Jennifer W. Li, Marino E. Leon, Maria D. Hurtado, Sergei Zolotukhin, Chen Liu, Jianrong Lu, James D. Griffin, Frederic J. Kaye, Lizi Wu
Published 2021-04-01

Inhibitors of the Transcription Factor STAT3 Decrease Growth and Induce Immune Response Genes in Models of Malignant Pleural Mesothelioma (MPM)

by Moshe Lapidot, Abigail E. Case, Dalia Larios, Helen I. Gandler, Chengcheng Meng, Isidora Tošić, Ellen L. Weisberg, Michael J. Poitras, Prafulla C. Gokhale, Cloud P. Paweletz, Klaus Podar, Ravi Salgia, Srinivas V. Saladi, James D. Griffin, David A. Frank, Raphael Bueno, Martin Sattler
Published 2021-12-01