Gata2 heterozygous mutant mice exhibit reduced inflammatory responses and impaired bacterial clearance

by Jun Takai, Takashi Shimada, Tadaho Nakamura, James Douglas Engel, Takashi Moriguchi
Published 2021-08-01

Transvection-like interchromosomal interaction is not observed at the transcriptional level when tested in the Rosa26 locus in mouse.

by Keiji Tanimoto, Hitomi Matsuzaki, Eiichi Okamura, Aki Ushiki, Akiyoshi Fukamizu, James Douglas Engel
Published 2019-01-01

Intergenic transcription, cell-cycle and the developmentally regulated epigenetic profile of the human beta-globin locus.

by Joanne Miles, Jennifer A Mitchell, Lyubomira Chakalova, Beatriz Goyenechea, Cameron S Osborne, Laura O'Neill, Keiji Tanimoto, James Douglas Engel, Peter Fraser
Published 2007-07-01

Biased, non-equivalent gene-proximal and -distal binding motifs of orphan nuclear receptor TR4 in primary human erythroid cells.

by Lihong Shi, M C Sierant, Katherine Gurdziel, Fan Zhu, Shuaiying Cui, Katarzyna E Kolodziej, John Strouboulis, Yuanfang Guan, Osamu Tanabe, Kim-Chew Lim, James Douglas Engel
Published 2014-05-01

Long non-coding RNA-dependent mechanism to regulate heme biosynthesis and erythrocyte development

by Jinhua Liu, Yapu Li, Jingyuan Tong, Jie Gao, Qing Guo, Lingling Zhang, Bingrui Wang, Hui Zhao, Hongtao Wang, Erlie Jiang, Ryo Kurita, Yukio Nakamura, Osamu Tanabe, James Douglas Engel, Emery H. Bresnick, Jiaxi Zhou, Lihong Shi
Published 2018-10-01

Oral tetrahydrouridine and decitabine for non-cytotoxic epigenetic gene regulation in sickle cell disease: A randomized phase 1 study.

by Robert Molokie, Donald Lavelle, Michel Gowhari, Michael Pacini, Lani Krauz, Johara Hassan, Vinzon Ibanez, Maria A Ruiz, Kwok Peng Ng, Philip Woost, Tomas Radivoyevitch, Daisy Pacelli, Sherry Fada, Matthew Rump, Matthew Hsieh, John F Tisdale, James Jacobberger, Mitch Phelps, James Douglas Engel, Santhosh Saraf, Lewis L Hsu, Victor Gordeuk, Joseph DeSimone, Yogen Saunthararajah
Published 2017-09-01