Ethanol impairs intestinal barrier function in humans through mitogen activated protein kinase signaling: a combined in vivo and in vitro approach.

by Elhaseen Elamin, Ad Masclee, Freddy Troost, Harm-Jan Pieters, Daniel Keszthelyi, Katarina Aleksa, Jan Dekker, Daisy Jonkers
Published 2014-01-01

Fatty acid ethyl esters induce intestinal epithelial barrier dysfunction via a reactive oxygen species-dependent mechanism in a three-dimensional cell culture model.

by Elhaseen Elamin, Ad Masclee, Kati Juuti-Uusitalo, Sven van Ijzendoorn, Freddy Troost, Harm-Jan Pieters, Jan Dekker, Daisy Jonkers
Published 2013-01-01

Effects of ethanol and acetaldehyde on tight junction integrity: in vitro study in a three dimensional intestinal epithelial cell culture model.

by Elhaseen Elamin, Daisy Jonkers, Kati Juuti-Uusitalo, Sven van Ijzendoorn, Freddy Troost, Hans Duimel, Jos Broers, Fons Verheyen, Jan Dekker, Ad Masclee
Published 2012-01-01

Differential effects of TNF (TNFSF2) and IFN-γ on intestinal epithelial cell morphogenesis and barrier function in three-dimensional culture.

by Kati Juuti-Uusitalo, Leon J Klunder, Klaas A Sjollema, Katarina Mackovicova, Ryuichi Ohgaki, Dick Hoekstra, Jan Dekker, Sven C D van Ijzendoorn
Published 2011-01-01

Dietary heme alters microbiota and mucosa of mouse colon without functional changes in host-microbe cross-talk.

by Noortje IJssennagger, Muriel Derrien, Gerdien M van Doorn, Anneke Rijnierse, Bartholomeus van den Bogert, Michael Müller, Jan Dekker, Michiel Kleerebezem, Roelof van der Meer
Published 2012-01-01

The effect of age on the intestinal mucus thickness, microbiota composition and immunity in relation to sex in mice.

by Marlies Elderman, Bruno Sovran, Floor Hugenholtz, Katrine Graversen, Myrte Huijskes, Eva Houtsma, Clara Belzer, Mark Boekschoten, Paul de Vos, Jan Dekker, Jerry Wells, Marijke Faas
Published 2017-01-01

Mucin Muc2 deficiency and weaning influences the expression of the innate defense genes Reg3β, Reg3γ and angiogenin-4.

by Nanda Burger-van Paassen, Linda M P Loonen, Janneke Witte-Bouma, Anita M Korteland-van Male, Adrianus C J M de Bruijn, Maria van der Sluis, Peng Lu, Johannes B Van Goudoever, Jerry M Wells, Jan Dekker, Isabelle Van Seuningen, Ingrid B Renes
Published 2012-01-01