Host immunity increases Mycobacterium tuberculosis reliance on cytochrome bd oxidase.

by Yi Cai, Eleni Jaecklein, Jared S Mackenzie, Kadamba Papavinasasundaram, Andrew J Olive, Xinchun Chen, Adrie J C Steyn, Christopher M Sassetti
Published 2021-07-01

<i>Mycobacterium tuberculosis</i> H₂S Functions as a Sink to Modulate Central Metabolism, Bioenergetics, and Drug Susceptibility

by Tafara T. R. Kunota, Md. Aejazur Rahman, Barry E. Truebody, Jared S. Mackenzie, Vikram Saini, Dirk A. Lamprecht, John H. Adamson, Ritesh R. Sevalkar, Jack R. Lancaster, Michael Berney, Joel N. Glasgow, Adrie J. C. Steyn
Published 2021-08-01

Bedaquiline reprograms central metabolism to reveal glycolytic vulnerability in Mycobacterium tuberculosis

by Jared S. Mackenzie, Dirk A. Lamprecht, Rukaya Asmal, John H. Adamson, Khushboo Borah, Dany J. V. Beste, Bei Shi Lee, Kevin Pethe, Simon Rousseau, Inna Krieger, James C. Sacchettini, Joel N. Glasgow, Adrie J. C. Steyn
Published 2020-11-01

Hydrogen sulfide stimulates Mycobacterium tuberculosis respiration, growth and pathogenesis

by Vikram Saini, Krishna C. Chinta, Vineel P. Reddy, Joel N. Glasgow, Asaf Stein, Dirk A. Lamprecht, Md. Aejazur Rahman, Jared S. Mackenzie, Barry E. Truebody, John H. Adamson, Tafara T. R. Kunota, Shannon M. Bailey, Douglas R. Moellering, Jack R. Lancaster, Adrie J. C. Steyn
Published 2020-01-01

Dual inhibition of the terminal oxidases eradicates antibiotic‐tolerant Mycobacterium tuberculosis

by Bei Shi Lee, Kiel Hards, Curtis A Engelhart, Erik J Hasenoehrl, Nitin P Kalia, Jared S Mackenzie, Ekaterina Sviriaeva, Shi Min Sherilyn Chong, Malathy Sony S Manimekalai, Vanessa H Koh, John Chan, Jiayong Xu, Sylvie Alonso, Marvin J Miller, Adrie J C Steyn, Gerhard Grüber, Dirk Schnappinger, Michael Berney, Gregory M Cook, Garrett C Moraski, Kevin Pethe
Published 2021-01-01