A Transitional Year Level to Higher Education: Challenges, Experiences and Self-regulatory Strategies during the Final Year of the University Preparatory Level

by Ernesto Panadero, Daniel García-Pérez, Javier Fernández-Ruiz, Héctor Sánchez-Centeno
Published 2020-10-01

Development of An Oral Treatment with the PPAR-γ-Acting Cannabinoid VCE-003.2 Against the Inflammation-Driven Neuronal Deterioration in Experimental Parkinson’s Disease

by Sonia Burgaz, Concepción García, Maria Gómez-Cañas, Eduardo Muñoz, Javier Fernández-Ruiz
Published 2019-07-01

Neuropathological Characterization of a Dravet Syndrome Knock-In Mouse Model Useful for Investigating Cannabinoid Treatments

by Valentina Satta, Valentina Satta, Valentina Satta, Cristina Alonso, Cristina Alonso, Cristina Alonso, Paula Díez, Paula Díez, Paula Díez, Soraya Martín-Suárez, Marta Rubio, Juan M. Encinas, Juan M. Encinas, Juan M. Encinas, Javier Fernández-Ruiz, Javier Fernández-Ruiz, Javier Fernández-Ruiz, Onintza Sagredo, Onintza Sagredo, Onintza Sagredo
Published 2021-01-01

Targeting cannabinoid CB2 receptors in the Central Nervous System. Medicinal chemistry approaches with focus on neurodegenerative disorders

by Gema Navarro, Paula Morales, Carmen Rodríguez-Cueto, Javier Fernández-Ruiz, Nadine Jagerovic, Rafael Franco
Published 2016-09-01

Neuroprotection with the Cannabidiol Quinone Derivative VCE-004.8 (EHP-101) against 6-Hydroxydopamine in Cell and Murine Models of Parkinson’s Disease

by Sonia Burgaz, Concepción García, María Gómez-Cañas, Alain Rolland, Eduardo Muñoz, Javier Fernández-Ruiz
Published 2021-05-01

Cannabinoids provide neuroprotection against 6-hydroxydopamine toxicity in vivo and in vitro: Relevance to Parkinson's disease

by Isabel Lastres-Becker, Francisco Molina-Holgado, José A. Ramos, Raphael Mechoulam, Javier Fernández-Ruiz
Published 2005-06-01

Pharmacokinetics of Sativex^® in Dogs: Towards a Potential Cannabinoid-Based Therapy for Canine Disorders

by María Fernández-Trapero, Carmen Pérez-Díaz, Francisco Espejo-Porras, Eva de Lago, Javier Fernández-Ruiz
Published 2020-02-01

Beneficial effects of the phytocannabinoid Δ9-THCV in L-DOPA-induced dyskinesia in Parkinson's disease

by Isabel Espadas, Ettel Keifman, Cristina Palomo-Garo, Sonia Burgaz, Concepción García, Javier Fernández-Ruiz, Rosario Moratalla
Published 2020-07-01

Endocannabinoid System in Spinocerebellar Ataxia Type-3 and Other Autosomal-Dominant Cerebellar Ataxias: Potential Role in Pathogenesis and Expected Relevance as Neuroprotective Ta...

by María Gómez-Ruiz, María Gómez-Ruiz, María Gómez-Ruiz, María Gómez-Ruiz, Carmen Rodríguez-Cueto, Carmen Rodríguez-Cueto, Carmen Rodríguez-Cueto, Eva Luna-Piñel, Eva Luna-Piñel, Eva Luna-Piñel, Eva Luna-Piñel, Mariluz Hernández-Gálvez, Mariluz Hernández-Gálvez, Mariluz Hernández-Gálvez, Mariluz Hernández-Gálvez, Javier Fernández-Ruiz, Javier Fernández-Ruiz, Javier Fernández-Ruiz
Published 2019-04-01

Pharmacological activation/inhibition of the cannabinoid system affects alcohol withdrawal-induced neuronal hypersensitivity to excitotoxic insults.

by Marina Rubio, Hélène Villain, Fabian Docagne, Benoit D Roussel, José Antonio Ramos, Denis Vivien, Javier Fernandez-Ruiz, Carine Ali
Published 2011-01-01

Upregulation of CB2 receptors in reactive astrocytes in canine degenerative myelopathy, a disease model of amyotrophic lateral sclerosis

by María Fernández-Trapero, Francisco Espejo-Porras, Carmen Rodríguez-Cueto, Joan R. Coates, Carmen Pérez-Díaz, Eva de Lago, Javier Fernández-Ruiz
Published 2017-05-01

Altered striatal endocannabinoid signaling in a transgenic mouse model of spinocerebellar ataxia type-3.

by Carmen Rodríguez-Cueto, Mariluz Hernández-Gálvez, Cecilia J Hillard, Patricia Maciel, Sara Valdeolivas, José A Ramos, María Gómez-Ruiz, Javier Fernández-Ruiz
Published 2017-01-01

Different susceptibility to the Parkinson's toxin MPTP in mice lacking the redox master regulator Nrf2 or its target gene heme oxygenase-1.

by Nadia G Innamorato, Agnieszka Jazwa, Ana I Rojo, Concepción García, Javier Fernández-Ruiz, Anna Grochot-Przeczek, Anna Stachurska, Alicja Jozkowicz, Jozef Dulak, Antonio Cuadrado
Published 2010-07-01

Decreased endocannabinoid levels in the brain and beneficial effects of agents activating cannabinoid and/or vanilloid receptors in a rat model of multiple sclerosis

by Ana Cabranes, Katerina Venderova, Eva de Lago, Filomena Fezza, Antonio Sánchez, Leyre Mestre, Marta Valenti, Antonio García-Merino, José Antonio Ramos, Vincenzo Di Marzo, Javier Fernández-Ruiz
Published 2005-11-01

Synthesis and pharmacological evaluation of new (E)- and (Z)-3-aryl-4-styryl-1H-pyrazoles as potential cannabinoid ligands

by Vera L. M. Silva, Artur M. S. Silva, Diana C. G. A. Pinto, Patricia Rodríguez, Maria Gómez, Nadine Jagerovic, Luis F. Callado, José A. S. Cavaleiro, José Elguero, Javier Fernández-Ruiz
Published 2010-08-01

Structure–Effect Relationships of Novel Semi-Synthetic Cannabinoid Derivatives

by Marcus R. Götz, Marcus R. Götz, Juan A. Collado, Juan A. Collado, Javier Fernández-Ruiz, Bernd L. Fiebich, Laura García-Toscano, María Gómez-Cañas, Oskar Koch, Andreas Leha, Eduardo Muñoz, Carmen Navarrete, Maria R. Pazos, Ulrike Holzgrabe
Published 2019-11-01

Benefits of VCE-003.2, a cannabigerol quinone derivative, against inflammation-driven neuronal deterioration in experimental Parkinson’s disease: possible involvement of different...

by Concepción García, María Gómez-Cañas, Sonia Burgaz, Belén Palomares, Yolanda Gómez-Gálvez, Cristina Palomo-Garo, Sara Campo, Joel Ferrer-Hernández, Carolina Pavicic, Carmen Navarrete, M. Luz Bellido, Moisés García-Arencibia, M. Ruth Pazos, Eduardo Muñoz, Javier Fernández-Ruiz
Published 2018-01-01

A53T-alpha-synuclein overexpression impairs dopamine signaling and striatal synaptic plasticity in old mice.

by Alexander Kurz, Kay L Double, Isabel Lastres-Becker, Alessandro Tozzi, Michela Tantucci, Vanessa Bockhart, Michael Bonin, Moisés García-Arencibia, Silke Nuber, Falk Schlaudraff, Birgit Liss, Javier Fernández-Ruiz, Manfred Gerlach, Ullrich Wüllner, Hartmut Lüddens, Paolo Calabresi, Georg Auburger, Suzana Gispert
Published 2010-07-01

Parkinson phenotype in aged PINK1-deficient mice is accompanied by progressive mitochondrial dysfunction in absence of neurodegeneration.

by Suzana Gispert, Filomena Ricciardi, Alexander Kurz, Mekhman Azizov, Hans-Hermann Hoepken, Dorothea Becker, Wolfgang Voos, Kristina Leuner, Walter E Müller, Alexei P Kudin, Wolfram S Kunz, Annabelle Zimmermann, Jochen Roeper, Dirk Wenzel, Marina Jendrach, Moisés García-Arencíbia, Javier Fernández-Ruiz, Leslie Huber, Hermann Rohrer, Miguel Barrera, Andreas S Reichert, Udo Rüb, Amy Chen, Robert L Nussbaum, Georg Auburger
Published 2009-06-01