Immune System Stimulation by Oncolytic Rodent Protoparvoviruses

by Assia Angelova, Jean Rommelaere
Published 2019-05-01

Overcoming Barriers in Oncolytic Virotherapy with HDAC Inhibitors and Immune Checkpoint Blockade

by Antonio Marchini, Eleanor M. Scott, Jean Rommelaere
Published 2016-01-01

PKCη/Rdx-driven phosphorylation of PDK1: a novel mechanism promoting cancer cell survival and permissiveness for parvovirus-induced lysis.

by Séverine Bär, Jean Rommelaere, Jürg P F Nüesch
Published 2015-03-01

Vesicular transport of progeny parvovirus particles through ER and Golgi regulates maturation and cytolysis.

by Séverine Bär, Jean Rommelaere, Jürg P F Nüesch
Published 2013-09-01

Parvovirus-Based Combinatorial Immunotherapy: A Reinforced Therapeutic Strategy against Poor-Prognosis Solid Cancers

by Assia Angelova, Tiago Ferreira, Clemens Bretscher, Jean Rommelaere, Antonio Marchini
Published 2021-01-01

Vesicular egress of non-enveloped lytic parvoviruses depends on gelsolin functioning.

by Séverine Bär, Laurent Daeffler, Jean Rommelaere, Jürg P F Nüesch
Published 2008-01-01

The Oncolytic Virotherapy Era in Cancer Management: Prospects of Applying H-1 Parvovirus to Treat Blood and Solid Cancers

by Assia L. Angelova, Mathias Witzens-Harig, Angel S. Galabov, Jean Rommelaere
Published 2017-05-01

Rational Combination of Parvovirus H1 With CTLA-4 and PD-1 Checkpoint Inhibitors Dampens the Tumor Induced Immune Silencing

by Katrin Goepfert, Christiane Dinsart, Jean Rommelaere, Friedrich Foerster, Markus Moehler
Published 2019-05-01

Immunotherapeutic Potential of Oncolytic H-1 Parvovirus: Hints of Glioblastoma Microenvironment Conversion towards Immunogenicity

by Assia L. Angelova, Milena Barf, Karsten Geletneky, Andreas Unterberg, Jean Rommelaere
Published 2017-12-01

Improved Killing of Human High-Grade Glioma Cells by Combining Ionizing Radiation with Oncolytic Parvovirus H-1 Infection

by Karsten Geletneky, Andreas D. Hartkopf, Robert Krempien, Jean Rommelaere, Joerg R. Schlehofer
Published 2010-01-01

Immune Conversion of Tumor Microenvironment by Oncolytic Viruses: The Protoparvovirus H-1PV Case Study

by Antonio Marchini, Antonio Marchini, Laurent Daeffler, Laurent Daeffler, Vitaly I. Pozdeev, Assia Angelova, Jean Rommelaere
Published 2019-08-01

Preclinical Testing of an Oncolytic Parvovirus: Standard Protoparvovirus H-1PV Efficiently Induces Osteosarcoma Cell Lysis In Vitro

by Carsten Geiss, Zoltán Kis, Barbara Leuchs, Monika Frank-Stöhr, Jörg R. Schlehofer, Jean Rommelaere, Christiane Dinsart, Jeannine Lacroix
Published 2017-10-01

Moving oncolytic viruses into the clinic: clinical-grade production, purification, and characterization of diverse oncolytic viruses

by Guy Ungerechts, Sascha Bossow, Barbara Leuchs, Per S Holm, Jean Rommelaere, Matt Coffey, Rob Coffin, John Bell, Dirk M Nettelbeck
Published 2016-01-01

TLR-9 contributes to the antiviral innate immune sensing of rodent parvoviruses MVMp and H-1PV by normal human immune cells.

by Zahari Raykov, Svitlana P Grekova, Rita Hörlein, Barbara Leuchs, Thomas Giese, Nathalia A Giese, Jean Rommelaere, Rainer Zawatzky, Laurent Daeffler
Published 2013-01-01

Preclinical Testing of an Oncolytic Parvovirus in Ewing Sarcoma: Protoparvovirus H-1 Induces Apoptosis and Lytic Infection In Vitro but Fails to Improve Survival In Vivo

by Jeannine Lacroix, Zoltán Kis, Rafael Josupeit, Franziska Schlund, Alexandra Stroh-Dege, Monika Frank-Stöhr, Barbara Leuchs, Jörg R. Schlehofer, Jean Rommelaere, Christiane Dinsart
Published 2018-06-01

Mutations in the Non-Structural Protein-Coding Sequence of Protoparvovirus H-1PV Enhance the Fitness of the Virus and Show Key Benefits Regarding the Transduction Efficiency of Der...

by Hamidreza Hashemi, Alexandra-Larisa Condurat, Alexandra Stroh-Dege, Nadine Weiss, Carsten Geiss, Jill Pilet, Carles Cornet Bartolomé, Jean Rommelaere, Nathalie Salomé, Christiane Dinsart
Published 2018-03-01

Activation of a helper and not regulatory human CD4+ T cell response by oncolytic H-1 parvovirus.

by Olivier Moralès, Audrey Richard, Nathalie Martin, Dhafer Mrizak, Magalie Sénéchal, Céline Miroux, Véronique Pancré, Jean Rommelaere, Perrine Caillet-Fauquet, Yvan de Launoit, Nadira Delhem
Published 2012-01-01

Pediatric and Adult High-Grade Glioma Stem Cell Culture Models Are Permissive to Lytic Infection with Parvovirus H-1

by Rafael Josupeit, Sebastian Bender, Sonja Kern, Barbara Leuchs, Thomas Hielscher, Christel Herold-Mende, Jörg R. Schlehofer, Christiane Dinsart, Olaf Witt, Jean Rommelaere, Jeannine Lacroix
Published 2016-05-01

A non-controlled, single arm, open label, phase II study of intravenous and intratumoral administration of ParvOryx in patients with metastatic, inoperable pancreatic cancer: ParvO...

by Jacek Hajda, Monika Lehmann, Ottheinz Krebs, Meinhard Kieser, Karsten Geletneky, Dirk Jäger, Michael Dahm, Bernard Huber, Tilman Schöning, Oliver Sedlaczek, Albrecht Stenzinger, Niels Halama, Volker Daniel, Barbara Leuchs, Assia Angelova, Jean Rommelaere, Christine E. Engeland, Christoph Springfeld, Guy Ungerechts
Published 2017-08-01

Virotherapy in Germany—Recent Activities in Virus Engineering, Preclinical Development, and Clinical Studies

by Dirk M. Nettelbeck, Mathias F. Leber, Jennifer Altomonte, Assia Angelova, Julia Beil, Susanne Berchtold, Maike Delic, Jürgen Eberle, Anja Ehrhardt, Christine E. Engeland, Henry Fechner, Karsten Geletneky, Katrin Goepfert, Per Sonne Holm, Stefan Kochanek, Florian Kreppel, Lea Krutzke, Florian Kühnel, Karl Sebastian Lang, Antonio Marchini, Markus Moehler, Michael D. Mühlebach, Ulrike Naumann, Roman Nawroth, Jürg Nüesch, Jean Rommelaere, Ulrich M. Lauer, Guy Ungerechts
Published 2021-07-01