Longitudinal imaging studies of tumor microenvironment in mice treated with the mTOR inhibitor rapamycin.

by Keita Saito, Shingo Matsumoto, Hironobu Yasui, Nallathamby Devasahayam, Sankaran Subramanian, Jeeva P Munasinghe, Vyomesh Patel, J Silvio Gutkind, James B Mitchell, Murali C Krishna
Published 2012-01-01

Pyruvate induces transient tumor hypoxia by enhancing mitochondrial oxygen consumption and potentiates the anti-tumor effect of a hypoxia-activated prodrug TH-302.

by Yoichi Takakusagi, Shingo Matsumoto, Keita Saito, Masayuki Matsuo, Shun Kishimoto, Jonathan W Wojtkowiak, William DeGraff, Aparna H Kesarwala, Rajani Choudhuri, Nallathamby Devasahayam, Sankaran Subramanian, Jeeva P Munasinghe, Robert J Gillies, James B Mitchell, Charles P Hart, Murali C Krishna
Published 2014-01-01