Applying Modern Transcriptomics to Interrogate the Human Cardiac Fibroblast∗

by Onur Kanisicak, PhD, Jeffery D. Molkentin, PhD
Published 2016-12-01

Parsing the roles of the transcription factors GATA-4 and GATA-6 in the adult cardiac hypertrophic response.

by Jop H van Berlo, Bruce J Aronow, Jeffery D Molkentin
Published 2013-01-01

Apoptosis repressor with a CARD domain (ARC) restrains Bax-mediated pathogenesis in dystrophic skeletal muscle.

by Jennifer Davis, Jennifer Q Kwong, Richard N Kitsis, Jeffery D Molkentin
Published 2013-01-01

Necroptosis Interfaces with MOMP and the MPTP in Mediating Cell Death.

by Jason Karch, Onur Kanisicak, Matthew J Brody, Michelle A Sargent, Demetria M Michael, Jeffery D Molkentin
Published 2015-01-01

Nemo-Like Kinase (NLK) Is a Pathological Signaling Effector in the Mouse Heart.

by Ruijie Liu, Hadi Khalil, Suh-Chin J Lin, Michelle A Sargent, Allen J York, Jeffery D Molkentin
Published 2016-01-01

Autophagic cell death is dependent on lysosomal membrane permeability through Bax and Bak

by Jason Karch, Tobias G Schips, Bryan D Maliken, Matthew J Brody, Michelle A Sargent, Onur Kanisicak, Jeffery D Molkentin
Published 2017-11-01

Postnatal ablation of Foxm1 from cardiomyocytes causes late onset cardiac hypertrophy and fibrosis without exacerbating pressure overload-induced cardiac remodeling.

by Craig Bolte, Yufang Zhang, Allen York, Tanya V Kalin, Jo El J Schultz, Jeffery D Molkentin, Vladimir V Kalinichenko
Published 2012-01-01

BEX1 is an RNA-dependent mediator of cardiomyopathy

by Federica Accornero, Tobias G. Schips, Jennifer M. Petrosino, Shan-Qing Gu, Onur Kanisicak, Jop H. van Berlo, Jeffery D. Molkentin
Published 2017-11-01

Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy

by Davy Vanhoutte, Tobias G. Schips, Alexander Vo, Kelly M. Grimes, Tanya A. Baldwin, Matthew J. Brody, Federica Accornero, Michelle A. Sargent, Jeffery D. Molkentin
Published 2021-06-01

The EYA3 tyrosine phosphatase activity promotes pulmonary vascular remodeling in pulmonary arterial hypertension

by Yuhua Wang, Ram Naresh Pandey, Allen J. York, Jaya Mallela, William C. Nichols, Yueh-Chiang Hu, Jeffery D. Molkentin, Kathryn A. Wikenheiser-Brokamp, Rashmi S. Hegde
Published 2019-09-01

Mitsugumin 29 regulates t-tubule architecture in the failing heart

by Robert N. Correll, Jeffrey M. Lynch, Tobias G. Schips, Vikram Prasad, Allen J. York, Michelle A. Sargent, Didier X. P. Brochet, Jianjie Ma, Jeffery D. Molkentin
Published 2017-07-01

The Mitochondrial Calcium Uniporter Selectively Matches Metabolic Output to Acute Contractile Stress in the Heart

by Jennifer Q. Kwong, Xiyuan Lu, Robert N. Correll, Jennifer A. Schwanekamp, Ronald J. Vagnozzi, Michelle A. Sargent, Allen J. York, Jianyi Zhang, Donald M. Bers, Jeffery D. Molkentin
Published 2015-07-01

Thrombospondin-3 augments injury-induced cardiomyopathy by intracellular integrin inhibition and sarcolemmal instability

by Tobias G. Schips, Davy Vanhoutte, Alexander Vo, Robert N. Correll, Matthew J. Brody, Hadi Khalil, Jason Karch, Andoria Tjondrokoesoemo, Michelle A. Sargent, Marjorie Maillet, Robert S. Ross, Jeffery D. Molkentin
Published 2019-01-01

TGFBI functions similar to periostin but is uniquely dispensable during cardiac injury.

by Jennifer A Schwanekamp, Angela Lorts, Michelle A Sargent, Allen J York, Kelly M Grimes, Demetria M Fischesser, Jason J Gokey, Jeffrey A Whitsett, Simon J Conway, Jeffery D Molkentin
Published 2017-01-01

Overexpression of Latent TGFβ Binding Protein 4 in Muscle Ameliorates Muscular Dystrophy through Myostatin and TGFβ.

by Kay-Marie Lamar, Sasha Bogdanovich, Brandon B Gardner, Quan Q Gao, Tamari Miller, Judy U Earley, Michele Hadhazy, Andy H Vo, Lisa Wren, Jeffery D Molkentin, Elizabeth M McNally
Published 2016-05-01

Genetic lineage tracing defines myofibroblast origin and function in the injured heart

by Onur Kanisicak, Hadi Khalil, Malina J. Ivey, Jason Karch, Bryan D. Maliken, Robert N. Correll, Matthew J. Brody, Suh-Chin J. Lin, Bruce J. Aronow, Michelle D. Tallquist, Jeffery D. Molkentin
Published 2016-07-01

Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice

by Jason Karch, Jennifer Q Kwong, Adam R Burr, Michelle A Sargent, John W Elrod, Pablo M Peixoto, Sonia Martinez-Caballero, Hanna Osinska, Emily H-Y Cheng, Jeffrey Robbins, Kathleen W Kinnally, Jeffery D Molkentin
Published 2013-08-01

Thrombospondin expression in myofibers stabilizes muscle membranes

by Davy Vanhoutte, Tobias G Schips, Jennifer Q Kwong, Jennifer Davis, Andoria Tjondrokoesoemo, Matthew J Brody, Michelle A Sargent, Onur Kanisicak, Hong Yi, Quan Q Gao, Joseph E Rabinowitz, Talila Volk, Elizabeth M McNally, Jeffery D Molkentin
Published 2016-09-01

MEF2C repressor variant deregulation leads to cell cycle re-entry and development of heart failure

by Ana Helena M. Pereira, Alisson C. Cardoso, Silvio R. Consonni, Renata R. Oliveira, Angela Saito, Maria Luisa B. Vaggione, Jose R. Matos-Souza, Marcelo F. Carazzolle, Anderson Gonçalves, Juliano L. Fernandes, Gustavo C.A. Ribeiro, Mauricio M. Lopes, Jeffery D. Molkentin, Kleber G. Franchini
Published 2020-01-01

Protein Kinase C Inhibition With Ruboxistaurin Increases Contractility and Reduces Heart Size in a Swine Model of Heart Failure With Reduced Ejection Fraction

by Thomas E. Sharp, III, BA, Hajime Kubo, PhD, Remus M. Berretta, BS, Timothy Starosta, BS, Markus Wallner, MD, PhD, Giana J. Schena, BS, Alexander R. Hobby, BS, Daohai Yu, PhD, Danielle M. Trappanese, PhD, Jon C. George, MD, Jeffery D. Molkentin, PhD, Steven R. Houser, PhD
Published 2017-12-01