TIME Is a Great Healer—Targeting Myeloid Cells in the Tumor Immune Microenvironment to Improve Triple-Negative Breast Cancer Outcomes

by Swarnima Singh, Xiang H. F. Zhang, Jeffrey M. Rosen
Published 2021-12-01

Notch Signaling as a Regulator of the Tumor Immune Response: To Target or Not To Target?

by Mahnaz Janghorban, Mahnaz Janghorban, Li Xin, Li Xin, Jeffrey M. Rosen, Jeffrey M. Rosen, Xiang H.-F. Zhang, Xiang H.-F. Zhang, Xiang H.-F. Zhang, Xiang H.-F. Zhang
Published 2018-07-01

Chk1 haploinsufficiency results in anemia and defective erythropoiesis.

by Nathan C Boles, Sirisha Peddibhotla, Alice J Chen, Margaret A Goodell, Jeffrey M Rosen
Published 2010-01-01

Stem cell antigen-1 (sca-1) regulates mammary tumor development and cell migration.

by Torey D Batts, Heather L Machado, Yiqun Zhang, Chad J Creighton, Yi Li, Jeffrey M Rosen
Published 2011-01-01

Mammary Stem Cells and Tumor-Initiating Cells Are More Resistant to Apoptosis and Exhibit Increased DNA Repair Activity in Response to DNA Damage

by Chi-Hsuan Chang, Mei Zhang, Kimal Rajapakshe, Cristian Coarfa, Dean Edwards, Shixia Huang, Jeffrey M. Rosen
Published 2015-09-01

The MMTV-Wnt1 murine model produces two phenotypically distinct subtypes of mammary tumors with unique therapeutic responses to an EGFR inhibitor

by Adam D. Pfefferle, David B. Darr, Benjamin C. Calhoun, Kevin R. Mott, Jeffrey M. Rosen, Charles M. Perou
Published 2019-07-01

Pregnancy-induced noncoding RNA (PINC) associates with polycomb repressive complex 2 and regulates mammary epithelial differentiation.

by Amy N Shore, Elena B Kabotyanski, Kevin Roarty, Martin A Smith, Yiqun Zhang, Chad J Creighton, Marcel E Dinger, Jeffrey M Rosen
Published 2012-01-01

Genomic profiling of murine mammary tumors identifies potential personalized drug targets for p53-deficient mammary cancers

by Adam D. Pfefferle, Yash N. Agrawal, Daniel C. Koboldt, Krishna L. Kanchi, Jason I. Herschkowitz, Elaine R. Mardis, Jeffrey M. Rosen, Charles M. Perou
Published 2016-07-01

Morphological screening of mesenchymal mammary tumor organoids to identify drugs that reverse epithelial-mesenchymal transition

by Na Zhao, Reid T. Powell, Xueying Yuan, Goeun Bae, Kevin P. Roarty, Fabio Stossi, Martina Strempfl, Michael J. Toneff, Hannah L. Johnson, Sendurai A. Mani, Philip Jones, Clifford C. Stephan, Jeffrey M. Rosen
Published 2021-07-01

Activation of Wnt signaling by chemically induced dimerization of LRP5 disrupts cellular homeostasis.

by Payam Shahi, Dongsu Park, Adam C Pond, Mamatha Seethammagari, Shin-Heng Chiou, Kyucheol Cho, Julienne L Carstens, William K Decker, Pierre D McCrea, Michael M Ittmann, Jeffrey M Rosen, David M Spencer
Published 2012-01-01

Genome-wide identification and differential analysis of translational initiation

by Peng Zhang, Dandan He, Yi Xu, Jiakai Hou, Bih-Fang Pan, Yunfei Wang, Tao Liu, Christel M. Davis, Erik A. Ehli, Lin Tan, Feng Zhou, Jian Hu, Yonghao Yu, Xi Chen, Tuan M. Nguyen, Jeffrey M. Rosen, David H. Hawke, Zhe Ji, Yiwen Chen
Published 2017-11-01

Targeting the Interplay between Epithelial-to-Mesenchymal-Transition and the Immune System for Effective Immunotherapy

by Rama Soundararajan, Jared J. Fradette, Jessica M. Konen, Stacy Moulder, Xiang Zhang, Don L. Gibbons, Navin Varadarajan, Ignacio I. Wistuba, Debasish Tripathy, Chantale Bernatchez, Lauren A. Byers, Jeffrey T. Chang, Alejandro Contreras, Bora Lim, Edwin Roger Parra, Emily B. Roarty, Jing Wang, Fei Yang, Michelle Barton, Jeffrey M. Rosen, Sendurai A. Mani
Published 2019-05-01

GSK3β regulates epithelial-mesenchymal transition and cancer stem cell properties in triple-negative breast cancer

by Geraldine Vidhya Vijay, Na Zhao, Petra Den Hollander, Mike J. Toneff, Robiya Joseph, Mika Pietila, Joseph H. Taube, Tapasree R. Sarkar, Esmeralda Ramirez-Pena, Steven J. Werden, Maryam Shariati, Ruli Gao, Mary Sobieski, Clifford C. Stephan, Nathalie Sphyris, Noayuki Miura, Peter Davies, Jeffrey T. Chang, Rama Soundararajan, Jeffrey M. Rosen, Sendurai A. Mani
Published 2019-03-01

The Oncogenic STP Axis Promotes Triple-Negative Breast Cancer via Degradation of the REST Tumor Suppressor

by Kristen L. Karlin, Gourish Mondal, Jessica K. Hartman, Siddhartha Tyagi, Sarah J. Kurley, Chris S. Bland, Tiffany Y.T. Hsu, Alexander Renwick, Justin E. Fang, Ilenia Migliaccio, Celetta Callaway, Amritha Nair, Rocio Dominguez-Vidana, Don X. Nguyen, C. Kent Osborne, Rachel Schiff, Li-Yuan Yu-Lee, Sung Y. Jung, Dean P. Edwards, Susan G. Hilsenbeck, Jeffrey M. Rosen, Xiang H.-F. Zhang, Chad A. Shaw, Fergus J. Couch, Thomas F. Westbrook
Published 2014-11-01