Natural history of disease in the YAC128 mouse reveals a discrete signature of pathology in Huntington disease

by Jeffrey B. Carroll, Jason P. Lerch, Sonia Franciosi, Amanda Spreeuw, Nagat Bissada, R. Mark Henkelman, Michael R. Hayden
Published 2011-07-01

HdhQ111 Mice Exhibit Tissue Specific Metabolite Profiles that Include Striatal Lipid Accumulation.

by Jeffrey B Carroll, Amy Deik, Elisa Fossale, Rory M Weston, Jolene R Guide, Jamshid Arjomand, Seung Kwak, Clary B Clish, Marcy E MacDonald
Published 2015-01-01

Peripheral huntingtin silencing does not ameliorate central signs of disease in the B6.HttQ111/+ mouse model of Huntington's disease.

by Sydney R Coffey, Robert M Bragg, Shawn Minnig, Seth A Ament, Jeffrey P Cantle, Anne Glickenhaus, Daniel Shelnut, José M Carrillo, Dominic D Shuttleworth, Julie-Anne Rodier, Kimihiro Noguchi, C Frank Bennett, Nathan D Price, Holly B Kordasiewicz, Jeffrey B Carroll
Published 2017-01-01

Allele-specific suppression of mutant huntingtin using antisense oligonucleotides: providing a therapeutic option for all Huntington disease patients.

by Niels H Skotte, Amber L Southwell, Michael E Østergaard, Jeffrey B Carroll, Simon C Warby, Crystal N Doty, Eugenia Petoukhov, Kuljeet Vaid, Holly Kordasiewicz, Andrew T Watt, Susan M Freier, Gene Hung, Punit P Seth, C Frank Bennett, Eric E Swayze, Michael R Hayden
Published 2014-01-01